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Table 2 Intervention data, fluid balance and laboratory outcome

From: Fluid management guided by a continuous non-invasive arterial pressure device is associated with decreased postoperative morbidity after total knee and hip replacement

 

CONTROL

PRESSURE

GDFT

P-value

(N = 40)

(N = 40)

(N = 40)

Length of the procedure (min)

110 (100–120)

105 (90–118)

100 (85–113)

0.06

MAP before anesthesia (mmHg)

119 (15)

113 (17)

114 (19)

0.31

MAP end of procedure (mmHg)

118 (14)

105 (12)bc

103 (18)bc

<0.001

HR before anesthesia (beats per minute)

73 (10)

72 (11)

68 (13)

0.20

HR end of procedure (beats per minute)

74 (14)

78 (16)c

77 (14)c

0.34

PPV after induction

N/A

7.9 (4.2) %

8.9 (4.5) %

0.36

PPV end of procedure

N/A

7.2 (2.4) %

8.2 (3.8) %

0.15

Hypotensive periods intraoperatively

3 (1–5)

2 (1–4)

2 (0–4)

0.09

Ephedrin (number of interventions)

2 (0–3)

0 (0–1)b

0 (0–1)b

<0.001

Ephedrin (dose - mg)

10 (0–15)

0 (0–10)

0 (0–10)

0.11

Hemoglobin before anesthesia (g/l)

136 (11)

121 (12) ab

131 (14)

<0.001

Hemoglobin end of procedure (g/l)

117 (15)

110 (13) ab

118 (16)

0.03

Lactate end of procedure (mmol/l)

N/A

1.2 (0.4)

1.2 (0.6)

0.99

Intraoperative fluid balance

Blood loss (ml)

500 (300–575)

500 (300–600)

400 (300–600)

0.77

Maintenance fluids (crystalloid) (ml)

1500 (1200–1500)

700 (600–750)b

750 (600–900)b

<0.001

Bolus fluids (colloid) (ml)

0 (0–500)

440 (100–500)b

400 (0–500)b

0.01

Patients receiving transfusion

5 (13 %)

3 (8 %)

1 (3 %)

0.24

Number of packed blood cells transfused

0 (0–0)

0 (0–0)

0 (0–0)

0.26

Early postoperative fluid balance (24 h)

Blood loss (ml)

735 (400–805)

470 (390–840)

500 (380–678)

0.42

Diuresis (ml)

1300 (1025–1625)

1000 (785–1378)b

1075 (900–1300)b

0.01

Crystalloids (ml)

2525 (2300–2800)

2800 (2300–3150)

2700 (2350–3125)

0.27

Colloids (ml)

0 (0–0)

0 (0–0)

0 (0–0)

0.70

Patients receiving transfusion

17 (43 %)

11 (28 %)

4 (10 %)b

0.01

Number of packed blood cells transfused

0 (0–2)

0 (0–2)

0 (0–0)b

0.01

Hemoglobin (24 h) (g/l)

105 (10)

102 (12) a

110 (14) a

0.01

Lactate (24 h) (mmol/l)

N/A

1.6 (0.8)

1.7 (0.8)

0.67

  1. Data are presented as mean (standard deviation), median (interquartil range) or number (proportion)
  2. PPV pulse pressure variation, HR heart rate, MAP mean arterial pressure
  3. a - significant difference between PRESSURE vs. GDFT groups
  4. b - significant difference between protocolled group (GDFT or PRESSURE) vs. CONTROL
  5. c - significant difference against baseline