Low tidal volume ventilation ameliorates left ventricular dysfunction in mechanically ventilated rats following LPS-induced lung injury

Table 1 Baseline measurements in the rats before randomization (n = 20)

Variable	LTV	LTV + LPS	HTV	HTV + LPS	P-value
Respiration
pH	7.31 ± 0.02	7.31 ± 0.03	7.30 ± 0.02	7.32 ± 0.05	0.66
PaCO₂ (torr)	40.3 ± 4.3	42.5 ± 4.1	42.6 ± 3.6	40.7 ± 3.1	0.68
PaO₂/FiO₂ (torr)	564 ± 60	538 ± 45	510 ± 31	525 ± 49	0.36
Pmean (cmH₂O)	7.6 ± 0.5	7.8 ± 0.4	7.4 ± 0.5	7.8 ± 0.8	0.70
Hemodynamics
MAP (mmHg)	100 ± 12	122 ± 23	105 ± 16	115 ± 23	0.28
CVP (mmHg)	1.4 ± 0.8	2.9 ± 0.9^a	1.5 ± 1.2	1.3 ± 0.4	0.045
HR (beats/min)	343 ± 35	407 ± 46	360 ± 26	378 ± 49	0.12
LV parameters
ESP (mmHg)	151 ± 16	157 ± 16	189 ± 36	174 ± 30	0.13
EDP (mmHg)	21 ± 9	16 ± 13	21 ± 5	18 ± 8	0.78
dP/dt_max (mmHg/s)	8043 ± 1689	8928 ± 2729	9912 ± 2709	8809 ± 2150	0.63
dP/dt_min (mmHg/s)	−10080 ± 1609	−11917 ± 2954	−9741 ± 2230	−11716 ± 2221	0.35
Ees/Ea	1.74 ± 0.64	2.03 ± 0.56	1.88 ± 0.89	1.74 ± 0.80	0.91

LTV low tidal volume ventilation, LPS lipopolysaccharide, HTV high tidal volume ventilation, CVP central venous pressure, dP/dt_max maximum rate of pressure development, dP/dt_min maximum rate of pressure decline, EDP end-diastolic pressure, ESP end-systolic pressure, Ees/Ea end-systolic elastance/effective arterial elastance ratio, HR heart rate, MAP mean arterial pressure, PaCO₂ arterial partial pressure of carbon dioxide, PaO₂/FiO₂ arterial partial pressure of oxygen/fraction of inspired oxygen ratio, Pmean mean airway pressure
^aCVP was higher in the LTV + LPS group compared to the other groups. Data are mean values ± SD

ISSN: 1471-2253