Preferential effects of low volume versus high volume replacement with crystalloid fluid in a hemorrhagic shock model in pigs

Table 1 Blood cell count and standard coagulation tests

	Baseline	Haemorrhage	Dilution	ANOVA
Hct (%)
LV	29.2 ± 2.1	25.6 ± 1.4	19.9 ± 1.5	p < 0.0001
HV	28.3 ± 1.6	24.7 ± 1.0	16.3 ± 1.7	p < 0.0001
	p = 0.27	p = 0.08	p < 0.0001
Plt (K/μL)
LV	380 ± 86	399 ± 75	318 ± 67	p < 0.0001
HV	361 ± 62	378 ± 71	231 ± 54	p < 0.0001
	p = 0.53	p = 0.47	p = 0.002
WBC (K/μL)
LV	15.6 ± 3.5	16.2 ± 5.1	19.0 ± 5.5	p = 0.021
HV	14.4 ± 3.7	14.5 ± 3.2	12.0 ± 3.7	p = 0.017
	p = 0.43	p = 0.36	p = 0.0014
PTI (%)
LV	113 ± 9	110 ± 8	102 ± 7	p = 0.0084
HV	110 ± 6	106 ± 7	92 ± 8	p < 0.0001
	p = 0.45	p = 0.23	p = 0.0031
aPTT (sec)
LV	13.5 ± 0.8	14.0 ± 0.6	14.4 ± 0.6	p = 0.012
HV	13.5 ± 0.7	13.8 ± 0.8	14.3 ± 1.1	p = 0.086
	p = 0.85	p = 0.45	p = 0.84
Fbg (mg/dL)
LV	386 ± 59	268 ± 38	205 ± 19	p < 0.0001
HV	350 ± 67	255 ± 43	168 ± 24	p < 0.0001
	p = 0.17	p = 0.45	p = 0.0004

Measurements at baseline, after 50 % haemorrhage and after fluid replacement (dilution) with an acetated, balanced crystalloid administering either with a low (LV, n = 12) or a high (HV, n = 12) volume strategy. P-values refer to differences between the two groups at each time-point. P-values of ANOVA refer to differences between time-points (baseline, haemorrhage, dilution)
Hct haematocrit, LV low volume resuscitation, HV high volume resuscitation, Plt platelet count, WBC white blood cells, PTI prothrombin time index, aPTT activated partial thromboplastin time, Fbg fibrinogen

ISSN: 1471-2253