Comparison of the effects of moderate and severe hypercapnic acidosis on ventilation-induced lung injury

BMC Anesthesiology

Table 2 Comparison of the level of TNF-a, IL-1β, and MIP-2 in BALF; MPO activity in lungs among groups

	NV group	NC group	MHA group	SHA group
TNF-a (pg/ml)	64 ± 18	335 ± 107*	141 ± 49*^†	93 ± 33*^#
IL-1β (pg/ml)	223 ± 76	1571 ± 421*	709 ± 205*^†	973 ± 224*^†
MIP-2 (pg/ml)	74 ± 19	479 ± 114*	113 ± 31*^†	190 ± 51*^†#
MPO (U/g)	0.3 ± 0.1	1.2 ± 0.4*	0.4 ± 0.1^†	0.8 ± 0.2*^†#

Values are means ± SD; n = 8.
NV = normal-pressure ventilation with a peak inspiratory pressure (PIP) of 15 cmH₂O; NC = high-pressure ventilation with a peak inspiratory pressure (PIP) of 30 cmH₂O; MHA = NC plus moderate hypercapnic acidosis (inhaled 11-12% CO₂to maintain Paco₂ = 80-100 mmHg); SHA = NC plus severe hypercapnic acidosis (inhaled 16-17% CO₂to maintain Paco₂ = 130-150 mmHg); BALF, bronchoalveolar lavage fluid; *p < 0.05 versus NV group;^†p < 0.05 versus NC group;^#p < 0.05 versus MHA group.

ISSN: 1471-2253