Hyperinflation deteriorates arterial oxygenation and lung injury in a rabbit model of ARDS with repeated open endotracheal suctioning

Table 2 Sequential changes of hemodynamics and pulmonary parameters

	Baseline	0	1	2	3
HR (bpm)
Control	298 ± 23.5	270 ± 24.2	254 ± 23.8	240 ± 19.6	246 ± 24.9
ARDS	282 ± 16.6	240 ± 17.1	243 ± 16.8	264 ± 13.9	231 ± 17.6
OES	229 ± 15.6	213 ± 16.2	223 ± 15.9	234 ± 13.1	220 ± 16.6
HI	259 ± 16.6	207 ± 17.1	218 ± 16.8	216 ± 13.9	212 ± 17.6
MAP (mm Hg)
Control	127 ± 7.40	106 ± 7.32	113 ± 7.32	105 ± 7.82	95.5 ± 11.8
ARDS	120 ± 5.23	102 ± 5.18	104 ± 5.45	98.4 ± 5.53	99.0 ± 8.33
OES	109 ± 4.94	102 ± 4.88	93.7 ± 5.56	103 ± 5.29	89.7 ± 7.85
HI	116 ± 5.23	113 ± 5.18	111 ± 5.45	98.3 ± 5.53	82.9 ± 8.33
pH
Control	7.40 ± 0.04	7.26 ± 0.05	7.17 ± 0.05	7.19 ± 0.04	7.19 ± 0.03
ARDS	7.41 ± 0.03	7.13 ± 0.04^c	7.13 ± 0.03	7.15 ± 0.03	7.12 ± 0.03
OES	7.43 ± 0.02	7.17 ± 0.03^c	7.17 ± 0.03	7.15 ± 0.03	7.16 ± 0.02
HI	7.47 ± 0.03	7.19 ± 0.04^c	7.15 ± 0.03	7.10 ± 0.03	7.08 ± 0.03
PIP (cm H₂O)
Control	12.8 ± 0.75	17.8 ± 1.44^c	18.8 ± 0.97	20.0 ± 1.05	19.2 ± 1.01
ARDS	12.9 ± 0.53	20.6 ± 1.01^c	21.3 ± 0.69	21.6 ± 0.74	20.4 ± 0.72
OES	13.9 ± 0.50	18.3 ± 0.96^c	21.2 ± 0.65	21.4 ± 0.70	22.2 ± 0.67
HI	12.5 ± 0.53	19.6 ± 1.02^c	21.0 ± 0.69	22.3 ± 0.74	23.7 ± 0.72^a,b
RR
Control	23.0 ± 2.66	33.0 ± 3.83^c	34.5 ± 4.21	40.5 ± 4.66	39.7 ± 5.24
ARDS	21.6 ± 1.88	33.7 ± 2.71^c	36.3 ± 2.98	35.0 ± 3.29	31.8 ± 3.71
OES	23.3 ± 1.88	36.3 ± 2.53^c	38.0 ± 2.98	39.6 ± 3.29	40.5 ± 3.71
HI	24.3 ± 1.88	34.3 ± 2.53^c	36.6 ± 2.98	39.5 ± 3.29	42.2 ± 3.71

MAP, mean arterial blood pressure; HR, heart rate; PIP, peak inspiratory pressure; RR, respiratory rate.
All values were mean ± SD.
^ap < 0.05 vs. Control group; ^bp < 0.05 vs. ARDS group; ^cp < 0.05 vs. previous adjacent value in the same group.

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