Figure 1

The sketch of the experimental protocol used in the present study. Same procedures were applied to 4 groups until baseline data were taken. After baseline data collection, rabbits of healthy control group received 3-hour mechanical ventilation without ARDS induction and subsequent intervention. Other groups (ARDS group, OES group and HI group) were applied each protocol; ARDS group was without undergoing intervention after saline lavage, OES group was performed the repeated open endotracheal suctioning every 30 min with ARDS, and HI group was added receiving hyperinflation intervention after open endotracheal suctioning (with ARDS).