Table 3 Clinical trials to assess the efficacy of open lung strategy
From: Perioperative lung protective ventilation in obese patients
Year | Author | Intervention | Recruitment maneuver | n | Weight (kg) | BMI | VT/BW | RR (breath/min) | PEEP | Outcome variables | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Continuous pressure | (mL/kg) | (cmH2O) | Oxygenation | Atelectasis | PACU or hospital stay | Postoperative pulmonary complications | ||||||||
Paw (cmH2O) | Time (s) | |||||||||||||
2007 | Chalhoub [128] | PEEP + RM40 | 40 | 15 | 26 | 130 (18) | 44.4 (3.7) | 10 | 12 (4) | 8 | ↑ | NA | NA | NA |
PEEP | 26 | 131 (23) | 45.5 (5.3) | 10 | 13 (3) | 8 | ||||||||
2009 | de Souza [129] | PEEP + RM30 | 30 | 120 | 16 | 123.7 (20.6) | 46.3 (5.0) | 8–10 | 12–14/min | 5 | ↗ | NA | NA | NA |
PEEP + RM10/15/20 | Stepwise method *1 | 17 | 136.4 (26.6) | 50.5 (7.2) | 8–10 | 12–14/min | 5 | NA | NA | NA | ||||
PEEP | 14 | 129.9 (22.4) | 49.2 (6.3) | 8–10 | 12–14/min | 5 | ↗ | |||||||
↑ | ||||||||||||||
2011 | Futier [130] | PEEP + NPPV + RM | 40 | 40 | 22 | 128 (17) | 45 (5) | 8 | 20 (20–21) | 10 | ↗ | (EELV) | NA | NA |
PEEP + NPPV | 22 | 128 (20) | 46 (2) | 8 | 20 (20–20) | 10 | (EELV) | NA | NA | |||||
PEEP | 22 | 130 (28) | 46 (4) | 8 | 20 (18–20) | 10 | ||||||||
2009 | Reinius [131] | RM + PEEP | 55 | 10 | 10 | 126 (9) | 45 (5) | 10 | 12/min | 10 | ↑ | ↓ | NA | NA |
RM + ZEEP | 55 | 10 | 10 | 130 (13) | 45 (4) | 10 | 12/min | 0 | → | → | NA | NA | ||
PEEP | 10 | 120 (14) | 44 (3) | 10 | 12/min | 10 | ||||||||
2009 | Talab [91] | RM + PEEP10 | 40 | 7–8 | 20 | NA | 44.5 (7.0) | 8–10 | NA | 10 | ↑ | ↓ | ↓ | ↓ |
RM + PEEP5 | 40 | 7–8 | 19 | NA | 38.3 (6.9) | 8–10 | NA | 5 | → | → | → | → | ||
RM + ZEEP | 19 | NA | 41.8 (7.9) | 8–10 | NA | 0 | ||||||||
2006 | Whalen [96] | RM + PEEP12 | Stepwise method *2 | 10 | NA | 48 (6) | 12.7 (1.5) | 17 (4) | 12 | ↑ | NA | → | → | |
PEEP4 | 10 | NA | 53 (11) | 11.8 (2.6) | 17 (4) | 4 | ||||||||
LBW: lean body weight | ||||||||||||||