Figure 2
From: Notch signaling activation is critical to the development of neuropathic pain
DAPT (an inhibitor of notch signaling pathway) administered before appearance of pain sensitivity significantly prevents the development of mechanical allodynia in SNI-induced neuropathic pain. A single administration of DAPT (50 μM, 10 μL, i.t.) was 0.5 h before SNI operation. The mechanical mechanical paw withdrawal threshold (PWT) was measured at 24 h before (baseline) as well as 7 d, 14 d, 21 d and 28 d after SNI or Sham operation. The data represent mean ± SD (n = 6 per group). *P < 0.05 versus Sham group; †P < 0.05 versus SNI group. SNI: spared nerve injury; BL: baseline; g: gram; d: day.