Table 2 Average serum and CSF concentrations of cefoperazone and sulbactam at every time point (mg/L)

Prior to administration

1.17±0.92(3) (0.51-2.22)

0.30±0.13(2) (0.2,0.39)

3.22±4.23(4) (0.2-9.4)

4.00±4.27(4) (0.38-10.07)

1

191.70±108.76(4) (33.45-281.39)

9.64±15.90(3) (0.44-28)

54.21±59.62(4) (15.29-143.09)

3.92±8.14(5) (0.07-18.48)

2

237.54±336.72(6) (14.84-891.77)

7.13±14.95(5) (0.28-33.87)

66.52±80.38(6) (3.7-223.15)

3.64±5.24(6) (0.18-14.07)

3

143.88±133.86(6) (30.21-343.82)

13.75±31.59(6) (0.05-78.21)

25.31±7.51(5) (13.19-33.27)

3.91±4.90(6) (0.18-13.33)

4

109.01±158.83(4) (21.23-346.98)

39.22±75.55(4) (1.05-152.55)

10.24±10.18(4) (2.23-25.05)

6.24±8.35(4) (0.55-18.59)

6

70.22±93.83(8) (3.42-282.65)

14.37±25.33(8) (0.38-75.76)

8.13±11.75(8) (0.1-30.27)

3.82±2.92(8) (0.42-10.01)

12

69.23±81.83(8) (3.62-192.77)

10.19±12.84(8) (0.33-36.38)

6.49±12.12(8) (0.32-36.29)

3.28±3.02(8) (0.33-9.56)

15

154.62±203.35(4) (35.58-457.64)

23.93±43.77(4) (0.32-89.55)

30.57±20.50(4) (13.61-56.46)

3.25±2.10(4) (0.27-5)

16

124.94±153.58(5) (22.17-386.35)

20.43±29.08(5) (0.62-68.35)

11.51±9.40(5) (4.69-27.66)

5.66±5.32(5) (0.41-13.65)

18

72.49±90.14(3) (3.28-174.42)

3.42±2.95(4) (0.28-7.21)

3.55±2.63(3) (0.61-5.67)

1.32±1.55(5) (0.16-3.86)