Population pharmacokinetics of remifentanil in infants and children undergoing cardiac surgery

BMC Anesthesiology

Table 3 Pharmacokinetic parameter estimates of remifentanil in pediatric patients undergoing cardiac surgery.

	This study^a			Pediatric^b	Adults^c	Adults^c	Pediatric^b	Adults^d
	Pre-CPB	CPB	Post-CPB	Pre-CPB		CPB	Post-CPB
Volumes (mL/kg)
V_c	124	298	298	72.7	41.8 (23–61)	65.9 (22.6–89.0)	83.5	22.6
V_d ^ss	124	298	298	235	1006 (245–1767)	344 (246–456)	235	456
Clearances (mL/min/kg)
CL	21.4	21.4	21.4	38.7	32.5 (32–33)	31 (25–35)	46.8	33
Q	N.A.	N.A.	N.A.	25.5	29.6 (28.7–30.5)	39.8 (28.7–51.2)	37.0	28.7
Half-lives (min)
Distribution	N.A.	N.A.	N.A.	0.73	0.43 (0.25–0.6)	0.55 (0.25–0.8)	0.63	0.25
Elimination	4.02	9.65	9.65	8.2	8.35 (6.4–10.3)	13.0 (7.2–19.8)	6.90	19.8

Abbreviations: CPB = cardiopulmonary bypass; V_c = central volume of distribution; V_d ^ss = volume of distribution at steady-state; CL = clearance; Q = intercompartmental clearance, N.A. = not applicable
^a Values are presented as population mean
^b Values are presented as mean as reported by Davis et al [3]
^c Values are presented as mean (range) values as reported by Michelsen et al and Russel et al [12, 13]
^d Values are presented as mean as reported by Michelsen et al [12]

ISSN: 1471-2253