Table 2 Population pharmacokinetic parameters and the stability of the parameters using the bootstrap resampling procedure.
From: Population pharmacokinetics of remifentanil in infants and children undergoing cardiac surgery
Original data | 1000 bootstrap replicates | |||
|---|---|---|---|---|
Mean estimate | 95% C.I. | Mean estimate | 95% C.I. | |
Structural model | ||||
Volume of distribution during pre-bypass, V (L) | 1.41 | 0.491, 2.33 | 1.57 | 0.943, 2.81 |
Clearance, CL (L/min) | 0.244 | 0.197, 0.291 | 0.249 | 0.201, 0.300 |
Effect of bypass and post-bypass on VPRE | 2.41 | 1.60, 3.22 | 2.26 | 1.66, 2.96 |
Inter-individual variability ω CL (%) | 33.8 | 19.7, 43.5 | 31.3 | 16.0, 41.1 |
Residual unexplained variability | ||||
Proportional residual error, coefficient of variation (%) | 43.8 | 25.1, 56.7 | 42.5 | 29.0, 57.3 |