Figure 4

Simulated pharmacokinetic profile of remifentanil during pre-cardiopulmonary bypass (CPB), intra-CPB and post-CPB for typical patients and receiving an initial loading dose of 18 μg and a 3.7 μg/min continuous infusion of remifentanil before, during and post-CPB with a supplemental bolus dose of 25 μg given at the start of CPB. The solid line represent the 50^th quantile (median) of the simulation, whereas the upper and lower dashed lines represent the 80^th and 20^th quantiles of the simulation, respectively. Arrows depict the start and stop times of CPB.