Figure 6

Blockade of sarcolemmal voltage-operated Ca ⁺⁺ channel (VOCC) attenuates the vasodilatory effect of sevoflurane. Sevoflurane produced significant dose dependent vasodilation of chorionic plate arterial rings compared to control conditions. Prior blockade of VOCC's by incubation in 1 × 10^-6 M verapamil (n = 10 rings per group) reduced the vasodilatory effect of sevoflurane. *P < 0.05 compared to rings exposed to control conditions. (Two way RM-ANOVA). † P < 0.05 compared to rings exposed to sevoflurane plus verapamil at graded sevoflurane concentrations (post hoc between group t test).