Figure 5
Blockade of K ATP channels enhances the vasodilatory effect of sevoflurane. Sevoflurane produced significant dose dependent vasodilation of chorionic plate arterial rings compared to control conditions. Prior blockade of KATP channels by incubation in 1 × 10-5 M glibenclamide (n = 10 rings per group) enhanced the vasodilatory effect of sevoflurane. *P < 0.05 compared to rings exposed to control conditions. (Two way RM-ANOVA). † P < 0.05 compared to rings exposed to sevoflurane plus vehicle at graded sevoflurane concentrations (post hoc between group t test).