Effect of propofol and etomidate on normoxic and chronically hypoxic pulmonary artery

BMC Anesthesiology

Table 1 R_max, pIC₃₀ and pIC₅₀ of etomidate on rat pulmonary and aorta and on human pulmonary artery precontracted by KCl and PHE

		R_max (%control)	pIC₃₀ (M)	pIC₅₀ (M)	n
normoxic rat PA	KCl	101.3 ± 0.8*†	4.32 ± 0.12*‡	4.06 ± 0.13*‡	7
	PHE	63.3 ± 9.7†‡°	3.78 ± 0.19†	3.03 ± 0.44†	7
human PA	KCl	84.7 ± 8.6*	3.74 ± 0.12‡	3.46 ± 0.12	7
	PHE	154.2 ± 22.4	3.64 ± 0.16	3.48 ± 0.14	7
CH rat PA	KCl	150.0 ± 22.4	4.59 ± 0.11	4.34 ± 0.10	9
	PHE	149.5 ± 19.0	4.55 ± 0.19	4.32 ± 0.19	6
normoxic rat aorta	KCl	107.0 ± 3.1	4.16 ± 0.10	3.87 ± 0.09†	9
	PHE	107.0 ± 1.6	4.12 ± 0.14	3.79 ± 0.09†	7
CH rat aorta	KCl	112.2 ± 6.6	4.38 ± 0.04	4.11 ± 0.06	8
	PHE	132.7 ± 28.7	4.54 ± 0.16	4.23 ± 0.17	6

Mean maximal relaxation to etomidate (R_max, % control), and mean 50% and 30% maximal contraction inhibitory concentrations (pIC₅₀ and pIC₃₀, M) in pulmonary artery (PA) and aorta from normoxic and chronically hypoxic (CH) rat and in human pulmonary artery precontracted with 80 mM KCl (KCl) and 10^-6 M phenylephrine (PHE). R_max, pIC₅₀ and pIC₃₀ values are mean ± SEM. *P < 0.05 KCl versus PHE; †P < 0.05 normoxic versus HC tissues; ‡P < 0.05 rat PA versus Human PA; °P < 0.05 PA versus aorta.

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