Table 1 Standard human PBPK organ weights, blood flows and fraction lipid
From: Human physiologically based pharmacokinetic model for propofol
Organ | Weight (Kg) | Fraction Lipid | Perfusion (L/Kg) | Total Flow (L/min) |
|---|---|---|---|---|
Blood | 5.5 | ≈0.01 |  |  |
liver | 1.8 | 0.25 | 0.25 | 0.45 |
portal | 1.5 | 0.02 | 0.75 | 1.125 |
muscle | 26 | 0.017 | 0.0225 | 0.585 |
kidney | 0.31 | 0.017 | 4 | 1.24 |
brain | 1.4 | 0.022 | 0.56 | 0.784 |
heart | 0.33 | 0.017 | 0.8 | 0.264 |
lung | 0.536 | 0.017 | 10.482 | 5.6184 |
skin | 2.6 | 0.017 | 0.1 | 0.26 |
tendon | 3 | 0.017 | 0.01 | 0.03 |
other | 5.524 | 0.017 | 0.02 | 0.1104 |
bone | 4 | 0 | 0 | 0 |
adipose | 17.5 | 0.8 | 0.0422 | 0.7385 |
Total | 70 | Â | Â | 5.5877 |