Oral valdecoxib and injected parecoxib for acute postoperative pain: a quantitative systematic review

BMC Anesthesiology

Table 3 NNT League table showing valdecoxib and parecoxib alongside other analgesics

Oral analgesics
Drug and dose	Number of patients in comparison	NNT (95% CI)
Valdecoxib 40 mg	473	1.6 (1.4 to 1.8)
Valdecoxib 20 mg	204	1.7 (1.4 to 2.0)
Rofecoxib 50 mg¹	675	2.3 (2.0 to 2.6)
Diclofenac 50 mg²	738	2.3 (2.0 to 2.7)
Ibuprofen 400 mg²	4703	2.4 (2.3 to 2.6)
Parenteral analgesics
Drug and dose	Number of patients in comparison	NNT (95% CI)
Parecoxib 40 mg IV	349	2.2 (1.8 to 2.7)
Morphine 10 mg IM³	946	2.9 (2.6 to 3.6)
Parecoxib 20 mg IV	346	3.0 (2.3 to 4.1)
Ketorolac 30 mg IM⁴	359	3.4 (2.5 to 4.9)

1. Barden et al. BMC Anesthesiol. 2002 Jun 9; 2(1):4. 2. In press update of Collins et al. Cochrane Database Syst Rev. 2000; (2):CD001548. 3. McQuay et al. JPSM. 1999 Mar; 17(3):164–174. 4. Smith et al. Brit J Anaesth. 2000; 84:48–58.

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