Do different anesthesia regimes affect hippocampal apoptosis and neurologic deficits in a rodent cardiac arrest model?

Table 1 Values of the arterial blood gas analysis 5 and 15 minutes after return of spontaneous circulation (median [IQR])

		Medetomidine/ketamine	Sevoflurane/fentanyl	p between groups Mann–Whitney test
pH	5 min	7.03 [IQR 6.93 – 7.09]	7.03 [IQR 6.95 – 7.15]	p = 0.44
	15 min	7.31 [IQR 7.24 – 7.34]	7.21 [IQR 7.07 – 7.32]
	p within groups Wilcoxon test	p < 0.01	p < 0.01
Base excess	5 min	-18.2 [IQR -20.1 – -15.6]	-16.3 [IQR -19.1 – -14.3]	p = 0.18
	15 min	-9.6 [IQR -12.0 – -7.6]	-10.0 [IQR -14.4 – -8.1]
	p within groups Wilcoxon test	p < 0.01	p < 0.01
pCO₂ [mmHg]	5 min	54.0 [IQR 39.9 – 64.3]	49.0 [IQR 42.5 – 67.5]	p = 0.83
	15 min	33.0 [IQR 29.8 – 38.0]	43.0 [IQR 33.0 – 53.0]
	p within groups Wilcoxon test	p < 0.01	p < 0.01
pO₂ [mmHg]	5 min	123 [IQR 113 – 1137]	110 [IQR 97 – 124]	p = 0.15
	15 min	141 [IQR 99 – 157]	92 [IQR 79 – 117]
	p within groups Wilcoxon test	p = 0.39	p = 0.01*
Lactate [mmol/l]	5 min	8.3 [IQR 6.9 – 10.7]	7.7 [IQR 7.4 – 9.3]	p = 0.86
	15 min	4.0 [IQR 3.1 – 6.7]	4.5 [IQR 3.8 – 4.7]
	p within groups Wilcoxon test	p < 0.01	p < 0.01
Glucose [mmol/l]	5 min	22.6 [IQR 20.4 – 25.3]	14.9 [IQR 13.3 – 16.4]	p < 0.01*
	15 min	21.9 [IQR 19.6 – 23.7]	13.1 [IQR 12.2 – 14.5]	p < 0.01*
	p within groups Wilcoxon test	p = 0.08	p = 0.01*

Mixed respiratory and metabolic acidosis are even distributed after cardiac arrest and corrects similarly in both groups. pO₂ is lower after 15 minutes in the sev/fnt group (significant decline from the 5 minutes value, compared to the med/ket group. Glucose values are always higher in the med/ket group due to the medetomedine (details see text) * indicate significant differences between the anesthesia groups.

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