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Table 2 Dixon’s method and isotonic regression

From: Adequate sedation with single-dose dexmedetomidine in patients undergoing transurethral resection of the prostate with spinal anaesthesia: a dose–response study by age group

Drug dose (μg/kg)

Group Y (n = 22)

Group O (n = 20)

Dixon’s method

ED50 (95% C.I.)

0.35 (0.35-0.45)

0.25 (0.15-0.35)

Isotonic regression method

ED50 (83% C.I.)†

0.41 (0.38-0.45)

0.24 (0.19-0.3)

ED95 (95% C.I.)‡

0.57 (0.49-0.59)

0.38 (0.29-0.39)

  1. ED50; 50% effective dose, ED95; 95% effective dose, C.I.; confidence interval Dixon’s method p value (non-parametric): 0.009.
  2. †Isotonic regression method 83% Confidence interval: do not overlap.
  3. ‡Isotonic regression method 95% Confidence interval: do not overlap.
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BMC Anesthesiology

ISSN: 1471-2253

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