Association between red blood cell storage duration and clinical outcome in patients undergoing off-pump coronary artery bypass surgery: a retrospective study

Table 2 Predictors for MACCEs

	Univariable analysis			Adjusted model 1^*			Adjusted model 2^†			Adjusted model 3^‡
	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
Total number of RBCs transfusion	1.04	1.03-1.05	<0.001	1.03	1.02-1.04	<0.001	1.03	1.02-1.04	<0.001	1.03	1.02-1.04	<0.001
Mean RBCs age	0.97	0.94-1.00	0.053	0.98	0.95-1.01	0.248
Maximum RBCs age	1.01	0.99-1.04	0.368				1.001	0.97-1.03	0.948
Any RBCs unit >14 days	1.01	0.75-1.35	0.957							0.89	0.65-1.24	0.504
Age	1.03	1.01-1.04	0.005
Male	0.94	0.68-1.28	0.679
Body mass index (kg m^-2)	0.99	0.95-1.04	0.652
Smoking	0.92	0.69-1.23	0.563
Diabetes mellitus	0.9	0.67-1.21	0.493
Hypertension	1.4	0.99-1.98	0.059
Dyslipidemia	1.13	0.81-1.58	0.47
Previous myocardial infarction	1.05	0.62-1.78	0.852
Previous stroke	1.27	0.87-1.88	0.221
Acute renal failure	1.97	0.73-5.33	0.179
Chronic renal failure	1.6	1.1-2.34	0.015
LV dysfunction (EF < 35%)	1.46	0.99-2.14	0.053
COPD	2.83	1.05-7.62	0.04
Previous cardiac surgery	1.24	0.58-2.65	0.572
Perioperative IABP insertion	1.77	1.30-2.40	<0.001
Emergent operation	1.59	1.13-2.24	0.008
Duration of surgery (min)	1	1.00-1.00	0.093
preoperative statin use	0.88	0.65-1.17	0.35
postoperative statin use	0.49	0.32-0.75	0.001	0.56	0.37-0.85	0.007	0.56	0.37-0.86	0.007	0.56	0.37-0.85	0.006
anesthetics (sevoflurane vs. propofol)	0.82	0.59-1.15	0.26
lowest intraoperative heart rate	0.99	0.98-1.01	0.828
lowest intraoperative mean arterial pressure	1	0.99-1.01	0.87
lowest intraoperative mixed venous saturation	1.02	0.99-1.04	0.24
lowest intraoperative cardiac index	0.8	0.48-1.35	0.4
lowest perioperative hematocrit	0.97	0.92-1.01	0.129

^*Adjusted model 1 was constructed including the mean RBCs age as a covariate.
^†Adjusted model 2 was constructed including the oldest RBCs age as a covariate.
^‡Adjusted model 3 was constructed including the ‘any RBCs unit >14 days’ as a covariate.
MACCE, major adverse cardiovascular and cerebral event; RBC, red blood cell; LV, left ventricle; EF, ejection fraction; COPD, chronic obstructive pulmonary disease; IABP, intra-aortic balloon pump.

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