Study protocol of a randomised controlled trial comparing perioperative intravenous insulin, GIK or GLP-1 treatment in diabetes–PILGRIM trial

Table 4 Treatment algorithm

Glucose measurement*	Insulin 1st bolus	If glucose increases after 1st bolus	If glucose increases after 2nd bolus
4-8 mmol/l	-	-	-
8-9 mmol/l	2 IU	4 IU	6 IU
9-10 mmol/l	3 IU	5 IU	7 IU
10-11 mmol/l	4 IU	8 IU	12 IU
11-12 mmol/l	5 IU	9 IU	13 IU
12-13 mmol/l	6 IU	12 IU	18 IU
13-14 mmol/l	7 IU	13 IU	19 IU
14-15 mmol/l	8 IU	15 IU	20 IU
15-16 mmol/l	9 IU	16 IU	21 IU
> 16 mmol/l**	10 IU	17 IU	22 IU

*If glucose is <4 mmol l⁻¹, give 4 g glucose iv (20 ml glucose 20%) measure again after 10 minutes and consult research physician. If glucose is <2.3 mmol l⁻¹ give 50 g glucose iv. (100 ml glucose 50%) measure again after 10 minutes and consult research physician. **Consult research physician. (multiply by 18 for mg dl⁻¹).

ISSN: 1471-2253