Table 2 Key model building steps and associated objective function changes

1-compartment - no size scaling

8350.263

2-compartment - no size scaling

5804.790

3-compartment – no size scaling

5762.275

3-compartment – no size scaling + individual study centre RUV

5210.072

+BOV

5024.826

+BOV + allometric scaling FFM

4956.866

+BOV + allometric scaling TBW

4942.960

+BOV + allometric scaling NFM

4927.983

+BOV + allometric scaling NFM Ffat_CL = 1

4924.844

+BOV + allometric scaling NFM Ffat_CL = 0

4946.221

+BOV + allometric scaling NFM Ffat_CL = 1 + F_AGEV

4908.588

+BOV + allometric scaling NFM Ffat_CL = 1 + F_AGEV + F_AGECL

4901.989

+BOV + allometric scaling NFM Ffat_CL = 1 + F_AGEV + F_AGECL + F_SEXCL

4900.663

+BOV + allometric scaling NFM Ffat_CL = 1 + F_AGEV + F_AGECL + F_PREGCL

-F_SEXCL

4893.125

+BOV + allometric scaling NFM Ffat_CL = 1 + F_AGEV + F_AGECL + F_PREGCL + F_ICCL

4888.551

+BOV + allometric scaling NFM Ffat_CL = 1 + F_AGEV + F_AGECL + F_PREGCL + F_ICVOL

-F_ICCL

4876.427

+BOV + allometric scaling NFM Ffat_CL = 1 + F_AGEV + F_AGECL + F_PREGCL + F_ICV + F_HDUCL

4875.677

+BOV + allometric scaling NFM Ffat_CL = 1 + F_AGEV + F_AGECL + F_PREGCL + F_ICV + F_ORTHOV

-F_HDUCL

4839.712

+BOV + allometric scaling NFM Ffat_CL = 1 + F_AGEV + F_AGECL + F_PREGCL + F_ICV + F_ORTHOV + F_ABDCL

4827.174

+BOV + allometric scaling NFM Ffat_CL = 1 + F_AGEV + F_PREGCL + F_ICV + F_ORTHOV + F_ABDCL

-F_AGECL

4827.284