Figure 5

Effect of ropivacaine on acute lung injury in ICAM-1 ^−/− mice. ALI, induced by either hyperinflation (HTV), bacterial lipopolysaccharide (LPS), or a combination of the two (“double-hit” model) in ICAM-1 ^−/− mice, was assessed by measuring (A) excess lung water (ELW), (B) extravascular plasma equivalents (EVPE), (C) permeability index, and (D) myeloperoxidase activity as described in Methods. Values shown are mean ± SD with n = 7, except for MPO activity (n = 3). ^# p < 0.05 vs. control (NS-NS-HTV); *p < 0.05 vs. LPS-NS-HTV.