Table 1 Characteristics and prognosis of stage IIIb-IV non-squamous NSCLC patients requiring mechanical ventilation with standard care or EGFR TKIs for rescue therapy
Variables | All Patients | Standard Care | EGFR TKIs | p-value |
|---|---|---|---|---|
Subjects | 83 | 60 | 23 | |
Age yrs | 68.0 (17) | 68.5 (18) | 68.0 (15) | 0.84 |
Gender | ||||
Female | 36 (43) | 24 (40) | 12 (52) | 0.45 |
Male | 47 (57) | 36 (60) | 11 (48) | |
Smoking | 34 (41) | 25 (42) | 9 (39) | 1.00 |
Co-morbidities | ||||
No | 43 (52) | 32 (53) | 11 (48) | 0.84 |
Yes | 40 (48) | 28 (47) | 12 (52) | |
ECOG-PS | ||||
0-2 | 26 (31) | 17 (28) | 9 (39) | 0.49 |
3-4 | 57 (69) | 43 (72) | 14 (61) | |
Type of lung cancer | ||||
Adenocarcinoma | 76 (92) | 55 (92) | 21 (91) | 1.00 |
Large cell | 7 (8) | 5 (8) | 2 (9) | |
Cancer status | ||||
Controlled | 11 (13) | 7 (12) | 4 (17) | 0.76 |
Uncontrolled, newly diagnosed | 36 (43) | 27 (45) | 9 (39) | |
Uncontrolled, progression | 36 (43) | 26 (43) | 10 (44) | |
Treatment before respiratory failure | ||||
Combined therapy | 24 (29) | 18 (30) | 6 (26) | 0.26 |
EGFR TKI only | 9 (11) | 4 (7) | 5 (22) | |
Chemotherapy only | 31 (37) | 23 (38) | 8 (35) | |
No treatment | 19 (23) | 15 (25) | 4 (17) | |
Indication for MV | ||||
Pulmonary | 58 (70) | 41 (68) | 17 (74) | 0.90 |
Sepsis | 11 (13) | 9 (15) | 2 (9) | |
Cardiac | 7 (8) | 5 (8) | 2 (9) | |
Neurologic | 7 (8) | 5 (8) | 2 (9) | |
APACHE II score, points | 23.0 (9) | 23.5 (11) | 23.0 (9) | 0.86 |
SAPS II score, points | 54.0 (19) | 54.5 (19) | 54.0 (23) | 0.84 |
SOFA score, points | 7.0 (5) | 7.0 (4) | 7.0 (5) | 0.70 |
Use of vasopressors | 39 (47) | 29 (48) | 10 (44) | 0.88 |
Positive blood culture | 15 (18) | 12 (20) | 3 (13) | 0.54 |
Outcomes | ||||
Hospital mortality | 55 (66) | 41 (68) | 14 (61) | 0.81 |
Ventilator- dependent > 100 days | 12 (15) | 8 (13) | 4 (17) | |
Successfully weaned from a ventilator | 16 (19) | 11 (18) | 5 (22) | |