Variable | Survivors n (%) | Non-survivors n (%) | P |
---|---|---|---|
n = 166 | n = 58 | ||
IHD within 48 hours | 9 (5.4) | 5 (8.6) | 0.386 |
CRRT within 48 hours | 11 (6.6) | 15 (25.9) | <0.01 |
Stress dose steroid | 61 (36.8) | 29 (50.0) | 0.076 |
Gram stain of organisms isolated from all cultures | |||
Fungi or parasite | 4 (2.4) | 1 (1.7) | 0.761 |
Gram positive | 48 (28.9) | 26 (44.8) | 0.027 |
Gram negative | 80 (48.2) | 21 (36.2) | 0.114 |
Polymicrobial | 34 (20.5) | 10 (17.2) | 0.593 |
Concomitant positive culture (when culture results available) | |||
Respiratory | 17 (13.4) | 8 (18.6) | 0.404 |
Urine | 53 (34.4) | 10 (20.4) | 0.065 |
Primary bacteremia | 16 (9.6) | 9 (15.5) | 0.221 |
Source of infection if secondary bacteremiaa,b | |||
Skin soft tissue | 20 (12.1) | 6 (10.3) | 0.727 |
Respiratory | 30 (18.1) | 11 (19.0) | 0.880 |
Urinary | 57 (34.3) | 9 (15.5) | 0.007 |
Intra-abdominal | 20 (12.1) | 16 (27.6) | 0.006 |
Unknown | 22 (13.3) | 5 (8.6) | 0.351 |
Source control procedure if intra-abdominal sourcec | 16 (80.0) | 13 (81.3) | 0.925 |
Median time to source control, hours (IQR)c | 13.5 (0.7-65.0) | 13.9 (4.9-51.4) | 0.568 |
Vasopressor for at least 1 hour | 96 (57.8) | 43 (74.1) | 0.028 |
Antimicrobials administeredd,e | |||
Carbapenem (not ertapenem) | 48 (28.9) | 11 (19.0) | 0.139 |
Cefepime | 33 (19.9) | 17 (29.3) | 0.138 |
Ceftriaxone | 20 (12.1) | 10 (17.2) | 0.318 |
Clindamycin | 9 (5.4) | 4 (6.9) | 0.679 |
Fluoroquinolone | 130 (78.3) | 43 (74.4) | 0.514 |
Levofloxacin | 103 (62.1) | 32 (55.2) | 0.357 |
Metronidazole | 12 (7.2) | 11 (19.0) | 0.011 |
Piperacillin/tazobactam | 89 (53.6) | 28 (48.3) | 0.484 |
Vancomycin | 142 (85.5) | 47 (81.0) | 0.416 |
Antifungal agent | 4 (2.4) | 2 (3.5) | 0.673 |
Appropriate antimicrobial therapy administered <1 hr | 128 (77.1) | 41 (70.7) | 0.328 |
Time to appropriate antimicrobial therapy, hours, median (IQR) | 0 (0-0.87) | 0.23 (0-1.08) | 0.033 |