Characteristics, management and outcomes of critically ill patients who are 80 years and older: a retrospective comparative cohort study

Table 3 Outcomes of patients in the three age groups

	50-64.9 yr-old N = 2467	65-79.9 yr-old N = 2617	≥ 80 yr-old N = 748	P-value*	P-value**	P-value***
Duration of mechanical ventilation (days), mean ± SD	6.4 ± 10.5	6.4 ± 10.4	6.9 ± 8.8	0.97	0.85	0.87
ICU LOS (days), mean ± SD	7.8 ± 11.4	7.8 ± 11.1	7.4 ± 8.7	0.98	0.42	0.33
Hospital LOS (days), mean ± SD	44.2 ± 97.6	45.1 ± 136.8	48.7 ± 189.1	0.78	0.54	0.63
ICU mortality, N (%)	637 (25.8)	723 (27.6)	217 (29.0)	0.15	0.08	0.46
Post-ICU mortality of all ICU survivors, N (%)	340 (18.6)	486 (25.7)	193 (36.4)	<0.0001	<0.0001	<0.0001
Post ICU mortality of patients without Do-Not-Resuscitate orders, N (%)	270 (15.7)	386 (22.4)	129 (30.1)	<0.0001	<0.0001	0.0007
Post ICU mortality of patients with Do-Not-Resuscitate orders, N (%)	70 (63.6)	100 (59.5)	64 (62.1)	0.49	0.82	0.67
28-day mortality^#, N (%)	719 (29.1)	838 (32.0)	275 (36.8)	0.03	<0.0001	0.02
Hospital mortality, N (%)	977 (39.6)	1208 (46.2)	410 (54.8)	<0.0001	<0.0001	<0.0001
Predicted mortality, mean % ± SD
APACHE II	44.9 ± 28.0	53.8 ± 27.0	56.7 ± 25.7	<0.0001	<0.0001	0.02
MPM₀ II	38.6 ± 30.1	46.7 ± 30.9	55.8 ± 29.0	<0.0001	<0.0001	<0.0001
MPM₂₄ II	41.2 ± 31.3	48.4 ± 31.5	54.4 ± 30.0	<0.0001	<0.0001	<0.0001
Standardized mortality rate, (95% confidence interval)	0.88 (0.84-0.92)	0.86 (0.82-0.89)	0.97 (0.90-1.03)

APACHE, Acute Physiology and Chronic Health Evaluation; ICU, intensive care unit; LOS, length of stay; MPM, Mortality Probability Model; SD, standard deviation.
*P-value between patients aged 50–64.9 and those 65–79.9 years.
**P-value between patients aged 50–64.9 and those ≥ 80 years.
***P-value between patients aged 65–79.9 and those ≥ 80 years.
# Patients discharged alive < 28 days after hospital admission were considered to be survivors.

ISSN: 1471-2253