Table 1 Institutional guidelines for intravenous and aerosolized colistin dosing
The Ohio State University Wexner Medical Center | Mayo clinic | Barnes-Jewish hospital | |
|---|---|---|---|
Intravenous colistin | |||
Loading dose | None | None | None |
Maintenance dose | CrCl>70 ml/min: 2.5 mg/kg every 12 hours | CrCl >80 ml/min: 5 mg/kg/day divided in two doses | CrCl>80 ml/min: 2.5 mg/kg every 12 hours |
CrCl 30-70 ml/min: 1.5 mg/kg every 24 hours | CrCl 50-80 mL/min: 2.5-3.8mg/kg/day divided in two doses | CrCl 40-80 ml/min: 1.25-1.9 mg/kg every 12 hours | |
CrCl<30 ml/min: 1.5 mg every 48 hours | CrCl 10-49 ml/min: 2.5 mg/kg every 24 hours | CrCl 25-40 ml/min: 1.25 mg/kg every 24 hours | |
IHD: 1.5 mg/kg every 48 hours after dialysis | CrCl <10 ml/min: 1.5 mg/kg every 24 hours | CrCl10-25 ml/min: 1.5 mg/kg every 36 hours | |
CRRT: 2.5 mg/kg every 24 hours | IHD: 1.5 mg/kg every 24 hours or 2-3mg/kg after dialysis only on dialysis days | CrCl<10 ml/min: 1.5 mg every 48 hours | |
CRRT: 2.5 mg/kg every 12-24 hours | IHD: 1.5 mg/kg three times weekly after dialysis only on dialysis days | ||
CRRT: 2.5 mg/kg every 48 hours | |||
Aerosolized colistin | |||
Dosing | 75 mg every 12 hours | 75 mg every 12 hours | 150 mg every 12 hours |
Nebulizer | Jet | Vibrating mesh | Jet |