Table 2 Traditional renal and acid–base parameters in the course of acute kidney injury (AKI)
Day -2 (n = 13) | Day -1 (n = 21) | Day 0 (n = 168) | Day +1 (n = 164) | Day +2 (n = 117) | ||
|---|---|---|---|---|---|---|
Urea (mg/dL) | No-AKI | - | - | 27 [21,46] | 29 [20,48] | 27 [19,45] |
transient | 37 [34,40] | 45 [40,68] | 68 [51,90] | 63 [42,89] | 48 [34,66] | |
persistent | 33 [20,42] | 47 [35,65] | 75 [60,115] | 84 [62,136] | 95 [58,132] | |
P | *0.00/ **0.30/ ***0.00 | 0.00/ 0.00/ 0.00 | 0.00/ 0.00/ 0.00 | |||
Creatinine (mg/dL) | No-AKI | - | - | 0.68 [0.55,0.82] | 0.69 [0.57,0.83] | 0.62 [0.54,0.76] |
transient | 0.66 [0.60,0.73] | 0.79 [0.63,0.94] | 1.24 [0.86,1.70] | 0.98 [0.81,1.45] | 0.82 [0.65,1.09] | |
persistent | 0.72 [0.58,0.80] | 0.91 [0.59,1.02] | 1.62 [1.17,2.55] | 1.73 [1.11-2.48] | 1.69 [1.07,2.38] | |
P | 0.00/ 0.02/ 0.00 | 0.00/ 0.00/ 0.00 | 0.00/ 0.00/ 0.02 | |||
24 h-urine output (mL/kg/h) | No-AKI | - | - | 1.13 [0.68,1.88] | 1.13 [0.81,2.24] | 1.39 [0.80,1.93] |
transient | 1.74 [1.40,2.15] | 0.65 [0.42,1.04] | 1.18 [0.79,1.95] | 1.36 [0.92,2.31] | 1.07 [0.68,2.08] | |
persistent | 1.31 [0.94,2.00] | 0.87 [0.60,1.67] | 0.83 [0.62,1.28] | 0.97 [0.48,1.42] | 0.93 [0.55,1.34] | |
P | 0.28/ 0.11/ 0.72 | 0.12/ 0.07/ 0.79 | 0.18/ 1.00/ 0.49 | |||
24 h-fluid balance (mL) | No-AKI | - | - | 408 [-492,973] | 220 [-419,765] | 160 [-655,685] |
transient | 514 [171,1130] | 890 [85,968] | -119 [-770,891] | -260 [-754,455] | -64 [-1082,1190] | |
persistent | 841 [174,1001] | 691 [30,1515] | 158 [-255,922] | 255 [-391,717] | 27 [-697,807] | |
P | 0.18/0.10/ 0.08 | 0.10/0.05/ 0.14 | 0.71/0.78/ 0.76 | |||
pH | No-AKI | - | - | 7.38 [7.33,7.42] | 7.39 [7.36,7.41] | 7.39 [7.37,7.42] |
transient | 7.38 [7.38,7.38] | 7.39 [7.31,7.43] | 7.36 [7.32,7.40] | 7.39 [7.35,7.41] | 7.40 [7.37,7.43] | |
persistent | 7.42 [7.38,7.48] | 7.41 [7.33,7.44] | 7.35 [7.30,7.40] | 7.38 [7.35,7.41] | 7.39 [7.36,7.42] | |
P | 0.04/ 0.51/ 0.26 | 0.32/ 0.38/ 1.00 | 0.80/ 0.43/ 0.73 | |||
PCO 2 (mmHg) | No-AKI | - | - | 41 [34,47] | 40 [35,46] | 40 [35,45] |
transient | 40 [38,51] | 45 [35,53] | 41 [33,46] | 41 [35,46] | 42 [37,48] | |
persistent | 39 [32,42] | 38 [33,44] | 37 [33,43] | 37 [31,43] | 37 [33,44] | |
P | 0.29/ 0.25/0.71 | 0.00/ 0.00/ 0.90 | 0.05/ 0.02/ 0.38 | |||
SBE (mEq/L) | No-AKI | - | - | -2.6 [-3.7,1.1] | -0.9 [-3.3,1.6] | 0.2 [-2.5,2.3] |
transient | 1.5 [-1.1,2.0] | -0.4 [-3.4,0.7] | -2.6 [-6.2,0.2] | -1.1 [-3.8,2.6] | 1.2 [-2.1,4.6] | |
persistent | 0.7 [-2.7,2.6] | 0.2 [-5.6,1.7] | -4.1 [-7.4,-0.4] | -3.2 [-6.6,-0.4] | -1.9 [-3.4,0.4] | |
P | 0.24/ 0.07/ 0.85 | 0.04/ 0.10/ 0.70 | 0.01/ 0.01/ 0.20 | |||
Bicarbonate (mEq/l) | No-AKI | - | - | 22.4 [20.8,25.8] | 23.7 [21.4,26.6] | 24.5 [22.2,26.7] |
transient | 26.9 [22.3,27.9] | 23.4 [22.3,26.7] | 22.1 [18.7,25.3] | 23.6 [20.6,27.2] | 25.4 [22.2,29.3] | |
persistent | 24.4 [21.9,26.3] | 24 [19.1,26.4] | 20.3 [17.5,24.5] | 21.5 [17.6,24.7] | 22.9 [20.5,25.3] | |
P | 0.07/ 0.07 / 0.85 | 0.027/ 0.042/ 0.847 | 0.00/ 0.01/ 0.20 | |||
2 h-creatinine clearance (mL/min) | No-AKI | - | - | 117.8 [55.9,180.0] | 111.7 [92.0,194.0] | 112.7 [63.9,228.1] |
transient | 57.7 [18.7-234.6] | 56.9 [13.4,202.8] | 66.5 [41.5,115.9] | 85.2 [51.6,194.7] | 76.0 [41.1,148.1] | |
persistent | 59.7 [32.2-114.5] | 25.9 [9.0,72.5] | 31.7 [19.0,49.5] | 29.7 [14.1,58.3] | 36.8 [15.2,69.0] | |
P | 0.00/ 0.00/ 0.03 | 0.00/ 0.00/ 0.24 | 0.01/ 0.35/ 0.36 |