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Table 1 Propylene glycol specimens showing confluent degenerative changes on histology

From: Absence of neurotoxicity with perineural injection of ultrasound gels: assessment using an animal model

PG concentration Perineural inflammation Confluent changes
Axon degeneration Myelin degeneration Intraneural inflammation
  n (%) n (%) n (%) n (%)
0% n=9 5 (56%) possible in 3 (33%) 0 (0%) 0 (0%) 0 (0%)
2.5% n=8 8 (100%) 0 (0%) 0 (0%) 0 (0%)
10% n=8 8 (100%) 0 (0%) 0 (0%) 0 (0%)
35% n=8 8 (100%) 0 (0%) * 0 (0%) * 2 (25%) *
70% n=9 9 (100%) 5 (56%) 5 (56%) 6 (66%)
  1. PG: Propylene glycol.
  2. * Two specimens showed patchy axonal and myelin degeneration with intraneural inflammation in smaller fascicles, rather than confluent changes.