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Table 1 Propylene glycol specimens showing confluent degenerative changes on histology

From: Absence of neurotoxicity with perineural injection of ultrasound gels: assessment using an animal model

PG concentration

Perineural inflammation

Confluent changes

Axon degeneration

Myelin degeneration

Intraneural inflammation

 

n (%)

n (%)

n (%)

n (%)

0% n=9

5 (56%) possible in 3 (33%)

0 (0%)

0 (0%)

0 (0%)

2.5% n=8

8 (100%)

0 (0%)

0 (0%)

0 (0%)

10% n=8

8 (100%)

0 (0%)

0 (0%)

0 (0%)

35% n=8

8 (100%)

0 (0%) *

0 (0%) *

2 (25%) *

70% n=9

9 (100%)

5 (56%)

5 (56%)

6 (66%)

  1. PG: Propylene glycol.
  2. * Two specimens showed patchy axonal and myelin degeneration with intraneural inflammation in smaller fascicles, rather than confluent changes.
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BMC Anesthesiology

ISSN: 1471-2253

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