Renal effects of dexmedetomidine during coronary artery bypass surgery: a randomized placebo-controlled study

BMC Anesthesiology

Table 3 Serum and urine osmolality

	Dexmedetomidine		Placebo
	S-Osmol mosm/kg	U-Osmol mosm/kg	S-Osmol mosm/kg	U-Osmol mosm/kg
5 min after cannulation	291 ± 4	583 ± 178	292 ± 4	625 ± 152
1 min after cross clamp removal	295 ± 4	326 ± 93	293 ± 5	353 ± 80
24 h after urinary catheter insertion	296 ± 9	618 ± 117	290 ± 7	649 ± 85
48 h after urinary catheter insertion	294 ± 7	579 ± 128	295 ± 19	506 ± 84

There were no significant differences between the groups, effect of time or treatment-time interaction in serum osmolality (S-Osmol). Urine osmolality (U-Osmol) initially decreased in both groups (p < 0.001 for time effect) without treatment effect. However, there was a significant treatment-time interaction in the ANOVA (p = 0.024) and in paired comparisons dexmedetomidine patients had significantly higher values 48 h after urinary catheter insertion (p = 0.02)

ISSN: 1471-2253