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Figure 1 | BMC Anesthesiology

Figure 1

From: High tidal volume mechanical ventilation-induced lung injury in rats is greater after acid instillation than after sepsis-induced acute lung injury, but does not increase systemic inflammation: an experimental study

Figure 1

P a O 2 /F I O 2 ratio and lung compliance. The PaO2/FIO2 ratio and compliance in rats ventilated for 4 h after acid instillation or during sepsis with low tidal volume (LVt) (6 mL/kg), with a positive end-expiratory pressure (PEEP) of 5 cm H2O or high tidal volume (HVt) (15 mL/kg), without PEEP. (A) PaO2/FIO2 ratio decreased after acid instillation irrespective of ventilation strategy. Mechanical ventilation (MV) after acid instillation decreased the PaO2/FIO2 ratio in contrast to HVt MV during sepsis. (B) Acid instillation decreased lung compliance as opposed to sepsis. No effects of MV were observed. * p < 0.001 for model compared to LVt and HVt sepsis, # p < 0.001 for interaction between model and MV. Open squares: LVt acid, open triangles: HVt acid, solid squares: LVt sepsis and solid triangles: HVt sepsis.

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BMC Anesthesiology

ISSN: 1471-2253

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