Table 1 Diagnostic criteria and organ dysfunction variables within the 2003 SCCM/ESICM/ACCP/ATS/SIS sepsis definitions
| Â | SCCM/ESICM/ACCP/ ATS/SIS 2003 original publication | SCCM/ESICM/ACCP/ ATS/SIS 2003 used in present study |
|---|---|---|
Diagnostic criteria for sepsis | ||
Infection | + | + |
General variables | Â | Â |
Temperature | < 36.0°C and/or >38.3°C | < 36.0°C and/or >38.3°C |
Heart rate | > 90 | > 90 |
Respiratory rate | > 30 | > 30 |
Altered mental status | + | n. a. |
Significant edema | + | + |
Positive fluid balance | > 20 ml/kg over 24 hrs | > 20 ml/kg over 24 hrs |
Hyperglycemia in absence of diabetes | > 120 mg/dl or 7.7 mmol/l | > 120 mg/dl or 7.7 mmol/l |
Inflammatory variables | Â | Â |
White blood cell count (WBC) | > 12,000/μl and/or < 4,000/μl and/or > 10% immature | > 12,000/μl and/or < 4,000/μl and/or (> 10% immature, n. a.) |
Plasma C-reactive protein | > 2 SD above normal | > 4 mg/l |
Plasma procalcitonin | > 2 SD above normal | n. a. |
Hemodynamic variables | Â | Â |
Arterial hypotension | SBP < 90 mmHg and/or MAP < 70 mmHg and/or SBP decrease > 40 mmHg | n. a. |
SvO2 | > 70% | n. a. |
Cardiac index | > 3.5 l/min/m2 | n. a. |
Organ dysfunction variables | Â | Â |
Arterial hypoxemia | PaO2/FiO2 < 300 | PaO2/FiO2 < 300 |
Acute oliguria | < 0.5 ml/kg/h or 45 mmol/l >2 h | < 0.5 ml/kg/h or 45 mmol/l >2 h |
Hypoperfusion or hypotension | + | n. a. |
Creatinin increase | > 0.5 mg/dl or 43 μmol/l | > 0.5 mg/dl or 43 μmol/l |
Coagulation abnormalities | INR >1.5 or aPTT >60 s | INR >1.5 or aPTT >60 s |
Ileus (absent bowel sounds) | + | + |
Thrombocytopenia, platelet count | < 100,000/μl | < 100,000/μl |
Hyperbilirubinemia, plasma total bilirubin | > 4 mg/dl or 70 μmol/l | > 4 mg/dl or 70 μmol/l |
Tissue perfusion variables | Â | Â |
Hyperlactatemia | > 1 mmol/l | > 1 mmol/l |