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Figure 1 | BMC Anesthesiology

Figure 1

From: Design and Organization of the Dexamethasone, Light Anesthesia and Tight Glucose Control (DeLiT) Trial: a factorial trial evaluating the effects of corticosteroids, glucose control, and depth-of-anesthesia on perioperative inflammation and morbidity from major non-cardiac surgery

Figure 1

Spending functions for alpha or type I error (on left vertical axis) and beta or type II error (on right vertical axis) as a function of information time on horizontal axis, where information time is the proportion of the maximum planned sample size available for a particular interim analysis. Lines represent the cumulative error spent throughout the trial. Beta is spent faster than alpha to allow the study to stop early more readily for futility than for efficacy. Lines are continuous, allowing flexibility in choice of monitoring times, but interim monitoring will only be done at the pre-specified times for this study.

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BMC Anesthesiology

ISSN: 1471-2253

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