First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial

BMC Anesthesiology

Table 4 Pharmacodynamic parameters

Parameter	Typical Value	95% Confidence Interval	CV%
E₀	0.158	-0.02 - 0.336	114
E_max	17.8	15.6 - 19.9	93.3
EC₅₀ ng/mL	7580	6699 - 8461	22.2
Gamma	6.28	5.03 - 7.53	35.6
K_e0(min^-1)	0.808	0.746 - 0.870	12.6
K_e0 half life (min)	0.858	0.797 - 0.929
Residual error	1.98	1.55 - 2.34

Confidence intervals were calculated as the typical parameter (geometric mean) estimate ± 1.96 x standard error of the estimate. The coefficient of variation (CV%) was calculated, where possible, as the square root of the variance of the eta variable associated with that parameter.

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