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Table 2 Pharmacokinetic parameter values for the interim model

From: First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial

Parameter

Typical Value

(SE)

CL mL kg1 min1

7.99

(0.0241)

Q2 mL kg1 min1

68.7

(2.97)

Q3 mL kg1min1

9.33

(0.506)

V1 mL/kg

57.7

(3.46)

V2 mL/kg

335

(9.90)

V3 mL/kg

993

(26.8)

  1. Data are typical values (standard error). CL = irreversible systemic clearance from the central compartment; Q2 = distribution clearance for the rapidly equilibrating peripheral compartment; Q3 = distribution clearance for the slowly equilibrating peripheral compartment; V1= volume of the central compartment; V2 = volume of the rapid peripheral compartment; V3 = volume of the slow peripheral compartment.
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BMC Anesthesiology

ISSN: 1471-2253

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