Table 1 Infusion study: induction of anaesthesia and recovery times
From: First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial
| Â | Median | Min | Max | Mean effect site concn[SD] | n |
|---|---|---|---|---|---|
2 mg kg-1 (n = 2) | Time in minutes | μg mL-1 |  | ||
Cessation of speech | 0.9 | 0.8 | 0.9 | 6.2 | 2 |
Eye closure | 0.9 | 0.8 | 0.9 | 6.2 | 2 |
Syringe drop | Â | Â | Â | Â | 0 |
Loss of eyelash reflex | 1.7 | 1.7 | 1.7 | 10.9 | 1 |
Eyes open on command | 2.1 | 2 | 2.2 | 8.3 | 2 |
Limb movement on command | 2.1 | 2 | 2.2 | 8.3 | 2 |
3 mg kg-1 (n = 5) | Â | Â | Â | Â | Â |
Cessation of speech | 0.8 | 0.5 | 0.9 | 8.3 [2.5] | 5 |
Eye closure | 0.8 | 0.8 | 1.1 | 10.3 [1.6] | 5 |
Syringe drop | 0.9 | 0.8 | 1.3 | 10.5 [1.5] | 3 |
Loss of eyelash reflex | 1.1 | 0.9 | 1.3 | 11.8 [2.1] | 5 |
Eyes open on command | 3.3 | 3.3 | 5.3 | 5.9 [1.3] | 5 |
Limb movement on command | 4.1 | 3.3 | 6.4 | 5.4 [1.4] | 5 |
4 mg kg-1 (n = 5) | Â | Â | Â | Â | Â |
Cessation of speech | 0.7 | 0.5 | 0.8 | 8.0 [1.4] | 5 |
Eye closure | 0.7 | 0.7 | 0.8 | 9.5 [0.7] | 5 |
Syringe drop | 0.9 | 0.7 | 1.2 | 12.2 [2.0] | 5 |
Loss of eyelash reflex | 1.2 | 1 | 2 | 15.5 [2.6] | 5 |
Eyes open on command | 5.3 | 3.2 | 9.2 | 6.4 [1.1] | 5 |
Limb movement on command | 5.8 | 3.7 | 9.4 | 6.1 [0.9] | 5 |