Figure 5
From: First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial
Plots demonstrating the performance of the final pharmacokinetic model.
Panels A and B show the observed ORG25435 plasma concentration versus the population model predicted and individualized model predictions, respectively, demonstrating the overall model goodness-of-fit. Panel C shows the absolute values of the weighted residuals (approximating to standard deviation units) for the individualized model (IWRES) versus the individualized predictions. Panel D shows the weighted residuals (WRES) versus time.