Treatment of established postoperative nausea and vomiting: a quantitative systematic review

Kazemi-Kjellberg, Faranak; Henzi, Iris; Tramèr, Martin R

doi:10.1186/1471-2253-1-2

BMC Anesthesiology

Table 2 Placebo-controlled trials

From: Treatment of established postoperative nausea and vomiting: a quantitative systematic review

Ref	Validity score	Comparison	Surgery	Early success			Late success			Sponsorship
					absence of			absence of
	random blinding dropouts	(number of patients in brackets)		time point	nausea	vomiting	time point	nausea	vomiting
Dolasetron
[40]	1/1/0	1) Dolasetron 12.5 mg iv (66) 2) Dolasetron 25 mg iv (65) 3) Dolasetron 50 mg iv (67) 4) Dolasetron 100 mg iv (68) 5) Placebo iv (71)	Mixed		no data		24 h	no data	16/66 18/65 25/67 17/68 8/71	Hoechst Marion Russel
[19]	2/1/0	1) Dolasetron 12.5 mg iv (130) 2) Dolasetron 25 mg iv (119) 3) Dolasetron 50 mg iv (124) 4) Dolasetron 100 mg iv (126) 5) Placebo iv (121)	Mixed	2 h	no data	72/130 60/119 60/124 64/126 33/121	24 h	no data	46/130 33/119 36/124 37/126 13/121	Hoechst Marion Russel
Granisetron
[41]	2/1/1	1) Granisetron 0.1 mg iv (128) 2) Granisetron 1 mg iv (133) 3) Granisetron 3 mg iv (125) 4) Placebo iv (133)	Mixed	6 h	51/128 54/133 53/125 22/133	68/128 77/133 75/125 35/133	24 h	34/128 40/133 46/125 17/133	49/128 61/133 61/125 26/133
Tropisetron
[34]	1/2/0	1) Tropisetron 0.5 mg iv (77) 2) Tropisetron 2 mg iv (80) 3) Tropisetron 5 mg iv (80) 4) Placebo iv (77)	Mixed	4 h	45/77 45/80 45/80 35/77	54/77 61/80 59/80 35/77	24 h	33/77 36/80 37/80 26/77	40/77 46/80 48/80 22/77	Sandoz
Ondansetron
[42]	2/2/0	1) Ondansetron 8 mg iv (35) 2) Placebo iv (36)	Laparoscopy	2 h	no data	17/35 3/36		no data		Glaxo
[17]	1/1/1	1) Ondansetron 1 mg iv (112) 2) Ondansetron 4 mg iv (112) 3) Ondansetron 8 mg iv (104) 4) Placebo iv (108)	Not specified		no data		24 h	no data	45/112 49/112 43/104 28/108	Glaxo
[16]	1/1/0	1) Ondansetron 1 mg iv (130) 2) Ondansetron 4 mg iv (119) 3) Ondansetron 8 mg iv (122) 4) Placebo iv (129)	Mixed	2 h	no data	74/130 73/119 70/122 39/129	24 h	no data	53/130 56/119 57/122 19/129	Glaxo
[30]	2/2/1	1) Ondansetron 0.1 mg/kg iv (192) 2) Placebo iv (183)	Paediatric	2 h	no data	150/192 63/183	24 h	no data	98/186 30/179	Glaxo
[44]	2/1/0	1) Ondansetron 8 mg iv (18) 2) Placebo iv (18)	Mixed	4 h	14/18 5/18	17/18 17/18		no data		Glaxo
[45]	1/1/1	1) Ondansetron 4 mg iv (58) 2) Metoclopramide 10 mg iv (57) 3) Placebo iv (60)	Gynaecologic laparoscopy	0.5 h	Only combined nausea+vomiting data		48 h	Only combined nausea+vomiting data
[43]	2/2/0	1) Ondansetron 0.1 mg iv (32) 2) Ondansetron 4 mg iv (29) 3) Ondansetron 16 mg iv (28) 4) Placebo iv (32)	Mixed	6 h	no data	7/32 12/29 15/28 5/32	24 h	no data	5/32 11/29 14/28 5/32	Glaxo
Propofol
[35]	1/2/0	1) Propofol 20 mg iv (24) 2) Propofol 40 mg iv (22) 3) Intralipid iv (23)	Day case	2 h	no data	21/24 17/22 13/23	no data
[46]	1/1/0	1) Propofol 3 mg iv (12) 2) Propofol 9 mg iv (12) 3) Propofol 27 mg iv (12) 4) Intralipid iv (12)	Gynecologic laparoscopy	1.5 h	4/12 3/12 3/12 3/12	10/12 11/12 7/12 10/12	no data			ICI Pharmaceuticals
[47]	2/1/0	1) Propofol 0.2 mg/kg iv (35) 2) Intralipid (35)	Adenectomy Tonsillectomy	1 h	no data	34/35 30/35	24 h	no data	13/35 20/35
Others
[48]	2/2/0	1) Midazolam 1 mg iv + 1 mg/h (10) 2) Placebo iv (10)	Any surgery	9 h	no data	9/10 3/10	no data
[33]	1/1/0	1) GR205171 25 mg iv (18) 2) Placebo iv (18)	Hysterectomy	2 h	10/18 4/18	14/18 5/18	24 h	Only combined nausea+vomiting data		Glaxo
[27]	1/1/0	1) Domperidone 10 mg iv (52) 2) Placebo iv (48)	Mixed	6 h	Only combined nausea+vomiting data		no data
[31]	2/0/0	1) Isopropyl alcohol vapor nasal (20) 2) Saline nasal (19)	Paediatric	1 h	18/20 8/19	7/20 2/19	no data

All trials are in adults, except "paediatric"

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