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Table 2 Placebo-controlled trials

From: Treatment of established postoperative nausea and vomiting: a quantitative systematic review

Ref Validity score Comparison Surgery Early success Late success Sponsorship
      absence of   absence of  
  random blinding dropouts (number of patients in brackets)   time point nausea vomiting time point nausea vomiting  
Dolasetron
[40] 1/1/0 1) Dolasetron 12.5 mg iv (66)
2) Dolasetron 25 mg iv (65)
3) Dolasetron 50 mg iv (67)
4) Dolasetron 100 mg iv (68)
5) Placebo iv (71)
Mixed   no data   24 h no data 16/66
18/65
25/67
17/68
8/71
Hoechst
Marion
Russel
[19] 2/1/0 1) Dolasetron 12.5 mg iv (130)
2) Dolasetron 25 mg iv (119)
3) Dolasetron 50 mg iv (124)
4) Dolasetron 100 mg iv (126)
5) Placebo iv (121)
Mixed 2 h no data 72/130
60/119
60/124
64/126
33/121
24 h no data 46/130
33/119
36/124
37/126
13/121
Hoechst
Marion
Russel
Granisetron
[41] 2/1/1 1) Granisetron 0.1 mg iv (128)
2) Granisetron 1 mg iv (133)
3) Granisetron 3 mg iv (125)
4) Placebo iv (133)
Mixed 6 h 51/128
54/133
53/125
22/133
68/128
77/133
75/125
35/133
24 h 34/128
40/133
46/125
17/133
49/128
61/133
61/125
26/133
 
Tropisetron
[34] 1/2/0 1) Tropisetron 0.5 mg iv (77)
2) Tropisetron 2 mg iv (80)
3) Tropisetron 5 mg iv (80)
4) Placebo iv (77)
Mixed 4 h 45/77
45/80
45/80
35/77
54/77
61/80
59/80
35/77
24 h 33/77
36/80
37/80
26/77
40/77
46/80
48/80
22/77
Sandoz
Ondansetron
[42] 2/2/0 1) Ondansetron 8 mg iv (35)
2) Placebo iv (36)
Laparoscopy 2 h no data 17/35
3/36
  no data   Glaxo
[17] 1/1/1 1) Ondansetron 1 mg iv (112)
2) Ondansetron 4 mg iv (112)
3) Ondansetron 8 mg iv (104)
4) Placebo iv (108)
Not specified   no data   24 h no data 45/112
49/112
43/104
28/108
Glaxo
[16] 1/1/0 1) Ondansetron 1 mg iv (130)
2) Ondansetron 4 mg iv (119)
3) Ondansetron 8 mg iv (122)
4) Placebo iv (129)
Mixed 2 h no data 74/130
73/119
70/122
39/129
24 h no data 53/130
56/119
57/122
19/129
Glaxo
[30] 2/2/1 1) Ondansetron 0.1 mg/kg iv (192)
2) Placebo iv (183)
Paediatric 2 h no data 150/192
63/183
24 h no data 98/186
30/179
Glaxo
[44] 2/1/0 1) Ondansetron 8 mg iv (18)
2) Placebo iv (18)
Mixed 4 h 14/18
5/18
17/18
17/18
  no data   Glaxo
[45] 1/1/1 1) Ondansetron 4 mg iv (58)
2) Metoclopramide 10 mg iv (57)
3) Placebo iv (60)
Gynaecologic laparoscopy 0.5 h Only combined nausea+vomiting data 48 h Only combined nausea+vomiting data  
[43] 2/2/0 1) Ondansetron 0.1 mg iv (32)
2) Ondansetron 4 mg iv (29)
3) Ondansetron 16 mg iv (28)
4) Placebo iv (32)
Mixed 6 h no data 7/32
12/29
15/28
5/32
24 h no data 5/32
11/29
14/28
5/32
Glaxo
Propofol
[35] 1/2/0 1) Propofol 20 mg iv (24)
2) Propofol 40 mg iv (22)
3) Intralipid iv (23)
Day case 2 h no data 21/24
17/22
13/23
no data  
[46] 1/1/0 1) Propofol 3 mg iv (12)
2) Propofol 9 mg iv (12)
3) Propofol 27 mg iv (12)
4) Intralipid iv (12)
Gynecologic laparoscopy 1.5 h 4/12
3/12
3/12
3/12
10/12
11/12
7/12
10/12
no data ICI Pharmaceuticals
[47] 2/1/0 1) Propofol 0.2 mg/kg iv (35)
2) Intralipid (35)
Adenectomy
Tonsillectomy
1 h no data 34/35
30/35
24 h no data 13/35
20/35
 
Others
[48] 2/2/0 1) Midazolam 1 mg iv + 1 mg/h (10)
2) Placebo iv (10)
Any surgery 9 h no data 9/10
3/10
no data  
[33] 1/1/0 1) GR205171 25 mg iv (18)
2) Placebo iv (18)
Hysterectomy 2 h 10/18
4/18
14/18
5/18
24 h Only combined nausea+vomiting data Glaxo
[27] 1/1/0 1) Domperidone 10 mg iv (52)
2) Placebo iv (48)
Mixed 6 h Only combined nausea+vomiting data no data  
[31] 2/0/0 1) Isopropyl alcohol vapor nasal (20)
2) Saline nasal (19)
Paediatric 1 h 18/20
8/19
7/20
2/19
no data  
  1. All trials are in adults, except "paediatric"