Study | Year | Country | Sample size | Mean age | Gender (M:F) (I/C) | Anesthesia | Intervention | Pain manage | Relevant outcome | Follow-up |
---|---|---|---|---|---|---|---|---|---|---|
(I/C) | ||||||||||
Gasbjerg et al. [17] | 2022 | Danish | 161/162 | 69/68 | 80:81/74:88 | S/G | 24Â mg DXM prior surgery | Oral paracetamol and ibuprofen prior and after surgery, LIA, PCA (morphine), Morphine for rescue analgesia. | VAS and adverse effects | 3Â months |
Lei et al. [18] | 2021 | China | 62/63 | 66.0 /66.0 | 12:50/8:55 | G | 10Â mg DXM prior to induction | LIA, oral diclofenac or an IM of morphine as required. | VAS, ROM, Inflammatory cytokines and adverse effects | 3Â months |
Cheng et al. [19] | 2021 | China | 49/49a | 63.7/64.8 | 10:45/12:43 | S | Oral prednisone (10Â mg qd, from pod1, for 2Â weeks) | Oral celecoxib prior surgery, LIA, celecoxib on pod1 and tramadol for 2Â weeks. | VAS and adverse effects | 3Â months |
Zhang et al. [20] | 2020 | China | 31/32 | 66.3/67.3 | 6:25/4:28 | G | 20Â mg DXM after anesthesia, 10Â mg DXM at 24 and 48Â h | PIA, enteric-coated diclofenac sodium bid. | Inflammatory cytokines and adverse effects | 1Â year |
Tammachote and Kanitnate [21]. | 2020 | Thailand | 50/50 | 67 /69 | 8:42/6:44 | S | 0.15Â mg/kg DXM after anesthesia | PIA, IV ketorolac or morphine as required during the pod2, oral naproxen, oral tramadol as required on pod3. Extended-released acetaminophen, nortriptyline and pregabalin at bedtime. | VAS, ROM and adverse effects | 3Â months |
Kim et al. [22] | 2020 | Korea | 45/44 | 69.3 /68.2 | 4:41/3:41 | S | 10Â mg DXM 1Â h prior surgery | PIA, PCA (fentanyl and Acupan), oral celecoxib, tramadol/acetaminophen, oral oxycodone, IV pethidine or fentanyl patches as emergency required. | VAS and adverse effects | 1Â week |
Chan et al. [23] | 2020 | China | 46/45 | 75.5/75.3 | 11:35/13:32 | S | 8Â mg DXM prior induction | LIA, PCA morphine, oral analgesic regimen (pregabalin, paracetamol and celecoxib). | VAS, ROM, Inflammatory cytokines and adverse effects | 1Â year |
Yu et al. [24] | 2019 | China | 45/43 | 65.1/64.2 | 19:26/17:26 | G | 10Â mg DXM after the anesthesia and repeated at 24Â h | Oral oxycodone or an IM of pethidine hydrochloride as required. | VAS, ROM, Inflammatory cytokines and adverse effects | 3Â months |
Chen et al. [25] | 2019 | China | 30/30 | 66.7/68.1 | 8:22/8:22 | S | 125Â mg MP on the induction | LIA, PCA Morphine, Oral or IV medications (Gabapentin, Esomeprazole, Paracetamol, Cefazolin, Tranexamic acid, Etoricoxib, Bisacodyl, Metoclopramide, Dihydrocodeine). | Inflammatory cytokines and adverse effects | 1Â year |
Xu et al. [26] | 2018 | China | 60/61 | 64.5/65.8 | 11:49/8:53 | G | 20Â mg DXM prior induction | PAI, oral diclofenac, oxycodone HCl or IM of morphine as required. | VAS, ROM, Inflammatory cytokines and adverse effects | 3Â months |
Wu et al. [27] | 2018 | China | 50/50 | 66.9/67.4 | 17:33/18:32 | G | 10Â mg DXM 1Â h prior surgery | MOAG from 1Â day prior operation (celecoxib, pregabalin), oral oxycodone or an IM of pethidine hydrochloride as required. | VAS, ROM, Inflammatory cytokines and adverse effects | 3Â months |
Li et al. [28] | 2018 | China | 36/32 | 63.9 /64.7 | 7:29/5:27 | NR | 100Â mg HC, 2Â h prior and 8Â h after surgery | Oral celecoxib, LIA, PCA, IM of pethidine hydrochloride as required. | VAS, ROM and adverse effects | 30Â days |
Dissanayake et al. [29] | 2018 | Australia | 41/40 | NR | NR | S/G | 8Â mg DXM at induction and at 24Â h | LIA, paracetamol, gabapentin for 2,3Â days post-surgery, oxycodone/naloxone for 4,5Â days, ibuprofen or celecoxib, oxycodone and tramadol slow release as required. | VAS and adverse effects | 6Â weeks |
Xu et al. [30] | 2018 | China | 54/54 | 63.6 /63.6 | 8:46/9:45 | G | 10Â mg DXM after anesthesia, 10Â mg DXM returned to the inpatient unit | PIA, MOAG from 1Â day prior operation (diclofenac, pregabalin), oral oxycodone or an IM of parecoxib as required. | VAS, ROM, Inflammatory cytokines and adverse effects | 3Â days |
Lindberg-Larsen et al. [31] | 2017 | Denmark | 33/30 | 65.0/67.7 | 13:20/15:15 | S | 125Â mg MP after anesthesia | Oral paracetamol, naproxen 1Â h prior surgery, LIA, oral paracetamol and naproxen. Opioids as request. | VAS, Inflammatory cytokines and adverse effects | 24Â h |
Lee et al. [32] | 2018 | Canada | 60/60 | 64.6/67 | 18:42/23:37 | S | 8Â mg DXM over 10Â min after block | Oral acetaminophen before surgery, LIA, PCA hydromorphone, oral acetaminophen, oral opioids (hydromorphone or oxycodone), IV ketorolac or subcutaneous opioids as needed, | VAS and adverse effects | 48Â h |
Morales-Munoz et al. [33] | 2015 | Spain | 27/27b | 68.8/68.8 | 8:19/6:21 | S | 8Â mg DXM | 0.5% ropivacaine (20Â ml) for FNB | VAS and adverse effects | 48Â h |
McLawhorn et al. [34] | 2015 | America | 11/12 | 68/66 | 3:8/3:9 | S | 100Â mg HSS 2Â h prior surgery, 2 more doses given 8Â h | PECA till day 2, acetaminophen and oral narcotic analgesics as needed | Adverse effects | hospital stay |
Backes et al. [35] | 2013 | America | 28/20 | NR | NR | G | 10Â mg DXM prior to induction | Oral extended release oxycodone, celecoxib prior surgery, intraarticular pain pumps of 0.5% bupivacaine, PCA hydromorphone, oral extended release oxycodone, hydrocodone/acetaminophen and/or IV hydromorphone as request. | ROM | 48Â h |
Koh et al. [36] | 2013 | Korea | 135/134 | 72.0/72.0 | 38:117/35:119 | S | 10Â mg DXM 1Â h prior surgery | MOAG prior surgery (sustained-release oxycodone, celecoxib, pregabalin and acetaminophen), Continuous FNB, PIA, PCA fentanyl, Oral celecoxib, pregabalin and acetaminophen or IM of ketoprofen as required. | VAS and adverse effects | 1Â year |
Lunn et al. [37] | 2011 | Denmark | 24/24 | 66/67 | 13:11/8:16 | S | 125Â mg MP prior anesthesia | LIA, IV sufentanil in PACU, oral oxycodone, celecoxib and slow-release acetaminophen, oral gabapentin and from the night of surgery up to the 6th. | VAS, Inflammatory cytokines and adverse effects | 30Â days |
Jules-Elysee et al. [38] | 2011 | America | 15/15c | 64 /71 | 6:9/9:6 | S | 100Â mg HC prior surgery, 2 dose eight hours apart | PECA(bupivacaine and hydromorphone), bilateral FNBs, oxycodone and acetaminophen as needed | VAS, Inflammatory cytokines and adverse effects | 6Â months |
Peng et al. [39] | 2021 | China | 60/60c | 65.1/65.1 | 4:56/4:56 | NR | 7Â mg betamethasone | PIA, PCA (morphine), parecoxib after for 3Â days and oral Loxoprofen Sodium, aminophenol oxycodone sed as emergency. | VAS, ROM and adverse effects | 3Â months |
Wang et al. [40] | 2021 | China | 52/50 | 65.1/63.9 | 17:35/15:35 | G | 10Â mg DXM | LIA, celecoxib, morphine hydrochloride injected subcutaneously as required. | VAS, ROM, Inflammatory cytokines and adverse effects | 3Â months |
El-Boghdadly et al. [41] | 2021 | United Kingdom | 68/72a | 63.1/65.8 | 34:34/25:47 | S | 8Â mg DXM | Oral acetaminophen and celecoxib preoperatively, LIA, IV fentanyl or hydromorphone at PACU, oral acetaminophen celecoxib. Oral oxycodone, hydromorphone or PCA with hydromorphone or morphine as request. | VAS, ROM and adverse effects | 1Â month |
Chan et al. [42] | 2020 | China | 45/45c | 66/66 | 31:14:/31:14 | S | 40Â mg TA | LIA, PCA. | VAS, ROM and adverse effects | 1Â year |
Tsukada et al. [43] | 2016 | Japan | 40/37 | 75 /72 | 5:35/5:32 | S | 40Â mg MP | LIA, IV flurbiprofen axetil, oral loxoprofen, diclofenac sodium as request. | VAS, ROM and adverse effects | 1Â year |
Kim et al. [44] | 2015 | Korea | 43/43 | 71.4/70.6 | 2:41/4:39 | S | 40 mg MP | Oral celecoxib and tramadol/acetaminophen for pre 1 day, LIA, PCA (fentanyl), Ketorolac and fentanyl patch for 3—6 day. Oral celecoxib, tramadol/acetaminophen. IM of pethidine or oral oxycodone was used on rescue. | VAS, ROM, Inflammatory cytokines and adverse effects | 7 days |
Ikeuchi et al. [45] | 2014 | Japan | 20/20 | 77 /76 | 2:18/4:16 | G | 6.6Â mg DXM | LIA, PCA (Fentanyl), oral loxoprofen tablets until POD5 and as needed. | VAS, Inflammatory cytokines and adverse effects | 3Â months |
Kwon et al. [46] | 2014 | Korea | 76/76c | 69.3/69.3 | 0:76/0:76 | S | 40Â mg TA | Oral celecoxib, ultracet and pregabalin prior operation, LIA, PCA (fentanyl and bupivacaine), oral celecoxib and ultracet bid. IM of ketoprofen as request. | Adverse effects | 6Â months |
Yue et al. [47] | 2013 | China | 36/36 | 70.2/69.3 | 4:32/4:32 | G | 1Â ml betamethasone | Oral celecoxib preoperatively and postoperatively, LIA, PCA (morphine), IM of morphine as required. | VAS, ROM and adverse effects | 1Â year |
Chia et al. [48] | 2013 | Australia | 39/40 | 68.9 /65.1 | NR | S | 40Â mg triamcinolone acetate | LIA, celecoxib for 2Â weeks. | VAS, ROM and adverse effects | 3Â months |
Seah et al. [49] | 2011 | Singapore | 50/50 | 67.9/65.4 | NR | S/G | 40Â mg TA | LIA, oral naproxen and PCA (morphine). | VAS, ROM and adverse effects | 2Â year |
Christensen et al. [50] | 2009 | America | 39/37 | 65.8/65.2 | 16:23/7:30 | G | 40Â mg MP acetate | Oral celecoxib, oxycodone and acetaminophen preoperatively, FNB, LIA, | VAS, ROM and adverse effects | 3Â months |
Li et al. [51] | 2021 | China | 45/45 | 66.1/68.2 | 15:30/8:37 | G | 10Â mg DXM at the induction, 10Â mg DXM, 100Â ml | Oral loxoprofen or celecoxib after hospital admission, LIA, oral Loxoprofen, IM parecoxib until hospital discharge, IM Morphine hydrochloride as required. | VAS, ROM, Inflammatory cytokines and adverse effects | 3Â months |
Hatayama et al. [52] | 2021 | Japan | 50/50 | 71.6 /72.3 | 12:38/5:45 | G | 10Â mg DXM 1Â h prior, 24Â h after surgery, 40Â mg TA | PIA, FNB, oral acetaminophen on pod1, IM pentazocine and transrectal administration of diclofenac as request. | VAS, Inflammatory cytokines and adverse effects | 1Â week |