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Table 2 Association between serum iCa and tCa levels and mortality in patients with AIS

From: Association between serum calcium and prognosis in patients with acute ischemic stroke in ICU: analysis of the MIMIC-IV database

Clinical outcomes

Non-adjusted Model

HR(95%CI) P value

Model I

HR(95%CI) P value

Model II

HR(95%CI) P value

Model III

HR(95%CI) P value

30-day mortality

 iCa (mmol/L)

  Q1 (iCa<1.07)

2.06(1.54,2.77)

<0.001

2.14(1.59,2.88)

<0.001

1.65(1.22,2.25)

<0.001

1.58(1.16,2.15)

0.004

  Q2 (1.07≤iCa< 1.12)

1.83(1.35,2.48)

<0.001

1.84(1.36,2.49)

<0.001

1.64(1.21,2.23)

0.001

1.55(1.13,2.11)

0.006

  Q3 (1.12≤iCa< 1.17)

1

 

1

 

1

 

1

 

  Q4 (1.17≤iCa)

1.43(1.06,1.94)

0.020

1.42(1.05,1.93)

0.023

1.55(1.14,2.12)

0.005

1.53(1.12,2.09)

0.008

 tCa (mg/dL)

  Q1 (tCa<7.9)

1.14(0.87,1.50)

0.328

1.21(0.93,1.59)

0.160

0.94(0.71,1.24)

0.64

0.85(0.63,1.14)

0.272

  Q2 (7.9≤tCa<8.4)

1.06(0.81,1.38)

0.669

1.09(0.84,1.42)

0.518

1.13(0.87,1.48)

0.36

1.04(0.80,1.37)

0.751

  Q3 (8.4≤tCa<9.0)

1

 

1

 

1

 

1

 

  Q4 (9.0≤tCa)

0.84(0.63,1.10)

0.206

0.81(0.61,1.07)

0.132

0.86(0.65,1.15)

0.31

0.83(0.62,1.10)

0.195

90-day mortality

 iCa (mmol/L)

  Q1 (iCa<1.07)

1.88(1.47,2.42)

<0.001

2.01(1.56,2.59)

<0.001

1.58(1.22,2.04)

<0.001

1.46(1.12,1.90)

0.004

  Q2 (1.07≤iCa< 1.12)

1.55(1.20,2.02)

0.001

1.58(1.21,2.05)

<0.001

1.44(1.11,1.88)

0.007

1.36(1.04,1.77)

0.026

  Q3 (1.12≤iCa<1.17)

1

 

1

 

1

 

1

 

  Q4 (1.17≤iCa)

1.28(0.99,1.66)

0.059

1.28(0.99,1.66)

0.063

1.42(1.09,1.84)

<0.01

1.43(1.10,1.87)

0.008

 tCa (mg/dL)

  Q1 (tCa<7.9)

1.12(0.88,1.42)

0.355

1.20(0.94,1.53)

0.137

0.91(0.71,1.17)

0.473

0.83(0.64,1.08)

0.175

  Q2 (7.9≤tCa<8.4)

1.07(0.85,1.35)

0.546

1.10(0.87,1.38)

0.424

1.16(0.92,1.47)

0.209

1.09(0.86,1.39)

0.455

  Q3 (8.4≤tCa<9.0)

1

 

1

 

1

 

1

 

  Q4 (9.0≤tCa)

0.83(0.65,1.06)

0.133

0.80(0.62,1.02)

0.071

0.87(0.68,1.11)

0.260

0.84(0.65,1.07)

0.16

365-day mortality

 iCa (mmol/L)

  Q1 (iCa<1.07)

1.70(1.36,2.12)

<0.001

1.85(1.48,2.31)

<0.001

1.48(1.18,1.86)

<0.001

1.37(1.09,1.73)

0.008

  Q2 (1.07≤iCa<1.12)

1.45(1.15,1.82)

0.002

1.48(1.17,1.86)

<0.001

1.36(1.08,1.72)

0.009

1.30(1.02,1.63)

0.033

  Q3 (1.12≤iCa<1.17)

1

 

1

 

1

 

1

 

  Q4 (1.17≤iCa)

1.11(0.89,1.40)

0.356

1.10(0.88,1.39)

0.403

1.23(0.97,1.55)

0.089

1.22(0.97,1.55)

0.093

 tCa (mg/dL)

  Q1 (tCa<7.9)

1.00(0.81,1.25)

0.988

1.08(0.87,1.35)

0.478

0.84(0.67,1.05)

0.127

0.81(0.64,1.03)

0.091

  Q2 (7.9≤tCa<8.4)

0.97(0.79,1.20)

0.783

0.98(0.80,1.21)

0.884

1.05(0.85,1.29)

0.663

1.03(0.83,1.28)

0.806

  Q3 (8.4≤tCa<9.0)

1

 

1

 

1

 

1

 

  Q4 (9.0≤tCa)

0.83(0.67,1.03)

0.087

0.79(0.63,0.98)

0.03

0.84(0.68,1.05)

0.128

0.80(0.65,1.00)

0.068

  1. Non-adjusted Model: not adjusted
  2. Mode I: adjusted for gender, race, age
  3. Mode II: adjusted for gender, race, age, MAP, respiratory rate, heart rate, temperature, spo2, SIRS, APS III, liver disease, malignancy, renal failure, hyperlipidemia, mechanical ventilation, RRT, thrombolytic drugs and Mechanical thrombectomy
  4. Model III: adjusted for gender, race, age, MAP, respiratory rate, heart rate, temperature, spo2, SIRS, APS III, liver disease, malignancy, renal failure, hyperlipidemia, mechanical ventilation, RRT, thrombolytic drugs, Mechanical thrombectomy, serum glucose, hemoglobin, platelet, WBC, creatinine, BUN, sodium, chloride, magnesium, bicarbonate, lactate, PH, phosphate and eGFR