Table 2 Coagulation and need of transfusion
All patients | Matched patients | |||||||
|---|---|---|---|---|---|---|---|---|
Variable | N | Discontinued, N = 89 | Continued, N = 114 | p-value1 | N | Discontinued, N = 60 | Continued, N = 60 | p-value1 |
Coagulation | ||||||||
Hemoglobin [mmol/L], median (IQR) | ||||||||
at sepsis onset | 203 | 6.50 (5.90, 7.90) | 6.50 (5.82, 7.65) | 0.69 | 120 | 6.40 (5.90, 8.03) | 6.65 (6.00, 7.80) | 0.54 |
at ICU discharge | 200 | 5.80 (5.30, 6.50) | 5.80 (5.40, 6.27) | 0.52 | 117 | 6.00 (5.40, 6.60) | 5.80 (5.40, 6.20) | 0.26 |
Activated partial thromboplastin [s], median (IQR) | ||||||||
at sepsis onset | 203 | 30 (26, 36) | 29 (26, 33) | 0.30 | 120 | 31 (26, 36) | 29 (27, 33) | 0.48 |
at ICU discharge | 200 | 32 (27, 38) | 30 (26, 37) | 0.074 | 117 | 31 (27, 37) | 30 (26, 40) | 0.52 |
Prothrombin time [s], median (IQR) | ||||||||
at sepsis onset | 203 | 83 (59, 94) | 84 (67, 94) | 0.17 | 120 | 79 (59, 95) | 80 (60, 93) | 0.91 |
at ICU discharge | 199 | 87 (67, 98) | 94 (82, 103) | 0.025 | 116 | 84 (64, 97) | 95 (81, 104) | 0.023 |
Need for transfusions | ||||||||
Transfusions required, n (%) | 203 | 59 (66.3%) | 84 (73.7%) | 0.28 | 120 | 39 (65.0%) | 43 (71.7%) | 0.56 |
Major bleeding events2, n (%) | 203 | 33 (37.1%) | 34 (29.8%) | 0.30 | 120 | 22 (36.7%) | 17 (28.3%) | 0.44 |
Red blood cell concentrates, n (%) | ||||||||
during ICU stay after sepsis onset | 203 | 51 (57.3%) | 81 (71.1%) | 0.054 | 120 | 31 (51.7%) | 41 (68.3%) | 0.093 |
during ICU stay | 203 | 54 (60.7%) | 83 (72.8%) | 0.072 | 120 | 34 (56.7%) | 42 (70.0%) | 0.18 |
during total hospital stay | 203 | 64 (71.9%) | 91 (79.8%) | 0.24 | 120 | 42 (70.0%) | 46 (76.7%) | 0.54 |
Platelet concentrates, n (%) | ||||||||
during ICU stay after sepsis onset | 203 | 21 (23.6%) | 19 (16.7%) | 0.29 | 120 | 13 (21.7%) | 11 (18.3%) | 0.82 |
during ICU stay | 203 | 25 (28.1%) | 20 (17.5%) | 0.089 | 120 | 15 (25.0%) | 12 (20.0%) | 0.66 |
during total hospital stay | 203 | 26 (29.2%) | 27 (23.7%) | 0.42 | 120 | 15 (25.0%) | 15 (25.0%) | > 0.99 |
Fresh frozen plasma concentrates, n (%) | ||||||||
during ICU stay after sepsis onset | 203 | 34 (38.2%) | 31 (27.2%) | 0.10 | 120 | 23 (38.3%) | 20 (33.3%) | 0.70 |
during ICU stay | 203 | 36 (40.4%) | 34 (29.8%) | 0.14 | 120 | 25 (41.7%) | 21 (35.0%) | 0.57 |
during total hospital stay | 203 | 42 (47.2%) | 44 (38.6%) | 0.25 | 120 | 28 (46.7%) | 26 (43.3%) | 0.85 |