Table 1 Patient characteristics
All patients | Matched patients | |||||||
|---|---|---|---|---|---|---|---|---|
Variable | N | Discontinued, N = 89 | Continued, N = 114 | p-valuec | N | Discontinued, N = 60 | Continued, N = 60 | p-valuec |
Male sex, n (%) | 203 | 53 (59.6%) | 78 (68.4%) | 0.24 | 120 | 38 (63.3%) | 37 (61.7%) | > 0.99 |
Age [years], mean (SD) | 203 | 72 (10) | 73 (11) | 0.77 | 120 | 73 (10) | 72 (11) | 0.60 |
Septic shock, n (%) | 203 | 71 (79.8%) | 86 (75.4%) | 0.50 | 120 | 46 (76.7%) | 46 (76.7%) | > 0.99 |
SAPS II score, mean (SD) | 195 | 50 (14) | 45 (12) | 0.017 | 116 | 50 (15) | 46 (12) | 0.18 |
SOFA, median (IQR) | 199 | 9 (7, 10) | 8 (6, 10) | 0.087 | 118 | 9 (7, 10) | 9 (7, 11) | 0.93 |
APACHE II score, mean (SD) | 195 | 22 (7) | 21 (7) | 0.22 | 116 | 22 (7) | 21 (7) | 0.24 |
Body temperature [°C], mean (SD) | 192 | 37.01 (1.89) | 37.37 (1.72) | 0.17 | 116 | 37.11 (1.92) | 37.11 (1.93) | > 0.99 |
T at sepsis onset [Gpt/L], median (IQR) | 203 | 191 (133, 272) | 230 (170, 327) | 0.014 | 120 | 201 (147, 296) | 214 (144, 303) | 0.71 |
T at ICU discharge [Gpt/L], median (IQR) | 200 | 187 (104, 276) | 264 (180, 368) | < 0.001 | 117 | 205 (84, 276) | 248 (176, 404) | 0.034 |
WBC before sepsis onset [109/L], median (IQR) | 183 | 14 (8, 21) | 15 (10, 21) | 0.33 | 111 | 13 (8, 21) | 15 (10, 22) | 0.40 |
Lactate first 24 h after sepsis onset [mmol/l], median (IQR) | 192 | 3.0 (1.7, 6.2) | 2.2 (1.5, 4.1) | 0.033 | 117 | 3.5 (1.6, 6.7) | 2.8 (1.7, 4.8) | 0.56 |
CRP first 24 h after sepsis onset [mg/L], median (IQR) | 178 | 210 (118, 270) | 201 (117, 285) | 0.84 | 104 | 205 (127, 270) | 186 (114, 274) | 0.63 |
PCT first 24 h after sepsis onset [ng/mL], median (IQR) | 166 | 7 (2, 22) | 6 (2, 20) | 0.47 | 99 | 7 (2, 30) | 6 (2, 21) | 0.81 |
Colonization with nosocomial pathogens at admission, n (%) | 202 | 12 (13.6%) | 7 (6.1%) | 0.089 | 119 | 8 (13.6%) | 4 (6.7%) | 0.24 |
Hospital-acquired nosocomial pathogen, n (%) | 203 | 15 (16.9%) | 16 (14.0%) | 0.69 | 120 | 11 (18.3%) | 8 (13.3%) | 0.62 |
Operation ± 3 days to sepsis onset, n (%) | 203 | 60 (67.4%) | 70 (61.4%) | 0.46 | 132 | 43 (71.7%) | 42 (70.0%) | > 0.99 |
Reason for pre-existing APT (%) | 203 | < 0.001 | 120 | 0.58 | ||||
Primary prevention | 23 (25.8%) | 8 (7.0%) | 9 (15.0%) | 6 (10.0%) | ||||
Secondary prevention | 66 (74,2%) | 106 (93.0%) | 51 (85.0%) | 54 (90.0%) | ||||
Comorbidities | ||||||||
Arterial hypertension, n (%) | 203 | 73 (82.0%) | 86 (75.4%) | 0.30 | 120 | 48 (80.0%) | 48 (80.0%) | > 0.99 |
Coronary artery disease, n (%) | 203 | 24 (27.0%) | 53 (46.5%) | 0.006 | 120 | 17 (28.3%) | 20 (33.3%) | 0.69 |
Atrial fibrillation, n (%) | 203 | 22 (24.7%) | 26 (22.8%) | 0.87 | 120 | 15 (25.0%) | 8 (13.3%) | 0.16 |
Myocardial infarction, n (%) | 202 | 15 (16.9%) | 34 (30.1%) | 0.032 | 120 | 12 (20.0%) | 13 (21.7%) | > 0.99 |
Peripheral artery occlusive disease, n (%) | 202 | 18 (20.2%) | 37 (32.7%) | 0.056 | 120 | 17 (28.3%) | 19 (31.7%) | 0.84 |
Cerebrovascular disease, n (%) | 202 | 28 (31.5%) | 34 (30.1%) | 0.88 | 120 | 19 (31.7%) | 19 (31.7%) | > 0.99 |
Peptic ulcer disease, n (%) | 202 | 11 (12.4%) | 17 (15.0%) | 0.68 | 120 | 7 (11.7%) | 10 (16.7%) | 0.60 |
Other pre-existing chronic diseasea, n (%) | 203 | 42 (47.2%) | 58 (50.9%) | 0.67 | 120 | 27 (45.0%) | 30 (50.0%) | 0.71 |
Pre-existing long-term treatment | ||||||||
Statins, n (%) | 203 | 30 (33.7%) | 63 (55.3%) | 0.003 | 120 | 22 (36.7%) | 28 (46.7%) | 0.35 |
Betablockers, n (%) | 203 | 52 (58.4%) | 75 (65.8%) | 0.31 | 120 | 39 (65.0%) | 35 (58.3%) | 0.57 |
Antihypertensive drugsb, n (%) | 203 | 63 (70.8%) | 83 (72.8%) | 0.76 | 120 | 43 (71.7%) | 42 (70.0%) | > 0.99 |
Source of sepsis | 196 | 0.85 | 116 | 0.69 | ||||
Abdominal, n (%) | 39 (46.4) | 57 (50.9) | 27 (47.4) | 33 (55.9) | ||||
Pulmonary, n (%) | 26 (31.0) | 33 (29.5) | 18 (31.6) | 13 (22.0) | ||||
Bone and soft tissue, n (%) | 6 (7.1) | 9 (8.0) | 4 (7.0) | 4 (6.8) | ||||
Other, n (%) | 13 (15.5) | 13 (11.6) | 8 (14.0) | 9 (15.3) | ||||