Table 2 Pooled biases (MDPE), inaccuracies (MDAPE), divergences, and wobbles (with 95% confidence intervals) during TCI of propofol formulated with medium- and long-chain triglycerides using the modified Marsh and Schnider models

Bias (%), MDPE

Overall

16.4 (12.7 to 20.1)^a

16.6 (13.2 to 20.2)^a

2 ~ 3 ug/ml

4.4 (0.02 to 8.8)

6.8 (1.8 to 11.9)

3.5 ~ 5 ug/ml

27.7 (24.8 to 30.7)

24.5 (21.8 to 27.2)

Inaccuracy (%), MDAPE

Overall

24.4 (21.8 to 26.9)

26.9 (23.9 to 29.6)

2 ~ 3 ug/ml

19.5 (16.9 to 22.1)

24.0 (19.9 to 28.0)

3.5 ~ 5 ug/ml

31.6 (28.8 to 34.4)

29.5 (27.1 to 32.0)

Divergence (%/h)

Overall

-3.3 (-4.7 to -1.8)

-7.2 (-11.8 to -6.0)

2 ~ 3 ug/ml

0.0 (-1.5 to 1.5)

-5.6 (-7.6 to -3.7)

3.5 ~ 5 ug/ml

-9.0 (-18.4 to 0.4)

11.6 (2.4 to 20.8)

Wobble (%)

Overall

11.7 (9.1 to 14.3)

8.8 (5.9 to 11.4)

2 ~ 3 ug/ml

12.2 (9.3 to 15.2)

12.8 (10.2 to 15.4)

3.5 ~ 5 ug/ml

6.3 (4.3 to 8.2)

4.9 (3.0 to 6.7)