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Table 2 Hemodynamic parameters at different time points in four groups (n = 75 per group)

From: Dose-dependent effects of intravenous methoxamine infusion during hip-joint replacement surgery on postoperative cognitive dysfunction and blood TNF-α level in elderly patients: a randomized controlled trial

 

C

M1

M2

M3

Mean arterial pressure (MAP) (mmHg)

 Baseline

89.7 ± 9.2

91.8 ± 9.3

91.5 ± 9.1

90.7 ± 8.9

 10 min_Anesthesia

69.7 ± 6.1a

87.5 ± 8.5c

90.5 ± 9.0c

92.8 ± 9.1c

 30 min_Anesthesia

71.5 ± 6.7a

88.1 ± 9.3c

92.8 ± 9.3c

94.4 ± 9.2c

 60 min_Anesthesia

72.8 ± 7.4a

90.2 ± 9.5c

97.7 ± 9.6c

111.9 ± 13.4acef

 End of operation

75.9 ± 8.1a

93.3 ± 10.3c

98.3 ± 10.5c

115.7 ± 13.6acef

Heart rate (HR) (beats/min)

 Baseline

81.5 ± 8.3

81.3 ± 8.4

82.3 ± 8.1

82.2 ± 8.2

 10 min_Anesthesia

67.5 ± 6.2a

65.7 ± 7.1 a

66.5 ± 7.4a

68.8 ± 7.8a

 30 min_Anesthesia

69.7 ± 8.2a

66.9 ± 8.7 a

66.6 ± 8.9a

67.9 ± 8.7a

 60 min_Anesthesia

71.3 ± 8.4a

68.5 ± 8.9 a

68.8 ± 8.7a

71.5 ± 8.9a

 End of operation

71.5 ± 8.6a

71.5 ± 8.5 a

71.3 ± 8.9a

71.6 ± 9.1a

Rate pressure product (RPP)

 Baseline

10,451.3 ± 269.5

10,487.6 ± 281.7

10,490.2 ± 290.8

10,498.6 ± 297.3

 10 min_Anesthesia

7572.7 ± 187.6a

9695.4 ± 295.4c

9605.6 ± 301c

9612.9 ± 308.5c

 30 min_Anesthesia

7691.3 ± 279.4a

9595.5 ± 297.3c

9609.8 ± 306.5c

9925.7 ± 315.7c

 60 min_Anesthesia

7718.6 ± 286.2a

9601.7 ± 305.7c

10,313.5 ± 287.3c

13,076.5 ± 356.2acef

 End of operation

7995.4 ± 297.3a

9611.8 ± 308.9c

10,482.7 ± 291.5c

13,218.6 ± 395.8acef

Central venous pressure (CVP) (cmH2O)

 Baseline

8.6 ± 1.2

8.7 ± 1.2

8.5 ± 1.3

8.6 ± 1.3

 10 min_Anesthesia

3.9 ± 1.1a

5.7 ± 1.0ac

5.8 ± 1.1ac

6.2 ± 1.1ac

 30 min_Anesthesia

4.0 ± 1.1a

6.0 ± 1.1ac

6.1 ± 1.0ac

6.4 ± 1.1ac

 60 min_Anesthesia

4.5 ± 1.0a

6.1 ± 1.0ac

6.3 ± 1.1ac

8.5 ± 1.2cef

 End of operation

4.7 ± 1.1a

6.3 ± 1.1ac

6.5 ± 1.0ac

8.7 ± 1.3cef

Saturation of peripheral oxygen (SpO2) (%)

 Baseline

98.6 ± 1.1

98.7 ± 1.1

98.8 ± 1.0

98.7 ± 1.2

 10 min_Anesthesia

98.1 ± 1.1

98.4 ± 1.1

98.6 ± 1.2

98.6 ± 1.1

 30 min_Anesthesia

98.5 ± 1.2

98.6 ± 1.0

98.7 ± 1.2

98.7 ± 1.0

 60 min_Anesthesia

98.4 ± 1.0

98.8 ± 1.1

98.7 ± 1.1

98.8 ± 1.1

 End of operation

98.3 ± 1.3

98.8 ± 1.1

98.8 ± 1.0

98.8 ± 1.1

Cardiac output (CO) (L/min)

 Baseline

6.99 ± 1.12

6.98 ± 1.16

7.07 ± 1.12

7.08 ± 1.12

 10 min_Anesthesia

4.44 ± 0.84a

6.06 ± 1.13c

6.21 ± 1.17c

6.44 ± 1.24c

 30 min_Anesthesia

4.68 ± 1.00a

6.31 ± 1.30c

6.30 ± 1.31c

6.47 ± 1.33c

 60 min_Anesthesia

4.93 ± 1.05a

6.48 ± 1.35c

6.52. ± 1.3c

9.04 ± 1.81acef

 End of operation

4.96 ± 1.08a

6.78 ± 1.34c

6.78 ± 1.39c

9.41 ± 1.91acef

Systolic volume (SV) (mL/beat)

 Baseline

85.3 ± 5.0

85.3 ± 5.4

85.4 ± 5.2

85.6 ± 5.1

 10 min_Anesthesia

65.3. ± 6.4a

91.2 ± 7.1c

92.5 ± 7.3c

92.7 ± 7.4c

 30 min_Anesthesia

66.4 ± 6.5a

93.4 ± 7.3c

93.6 ± 7.2c

94.2 ± 7.5c

 60 min_Anesthesia

68.3 ± 6.7a

93.6 ± 7.5c

93.8 ± 7.3c

125.2 ± 9.7acef

 End of operation

68.6 ± 6.9a

93.9 ± 7.6c

94.1 ± 7.8c

130.2 ± 10.1acef

  1. Data are presented as mean ± standard deviation (SD)
  2. a P < 0.05, compared with that at 10 min before anesthesia induction
  3. c P < 0.05, compared with the control group (C)
  4. e P < 0.05, compared with the M1 group
  5. f P < 0.05, compared with the M2 group