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Table 3 Postoperative outcomes

From: A pragmatic multi-center trial of goal-directed fluid management based on pulse pressure variation monitoring during high-risk surgery

 

Original Cohort

Matched Cohort

Control (n = 147)

Intervention (n = 109)

P

Control (n = 84)

Intervention (n = 84)

P

At the time of ICU admission

 HR (BPM), mean ± SD

77 ± 16

79 ± 14

0.51

79 ± 16

77 ± 14

0.40

 MAP (mmHg), mean ± SD

93 ± 20

89 ± 20

0.25

89 ± 22

90 ± 20

0.77

 Lactate (mmol/l), median (IQ 25–75)

2.1 (1.5 - 3.5)

2.6 (1.8 - 3.7)

0.48

2.6 (1.8-4.3)

2.5 (1.5-3.2)

0.55

 CVP (mmHg) median (IQ 25–75)

10 (6.2 - 13.0)

9 (5 – 10)

0.04

10 (6.0 – 13)

9 (5-10)

0.13

At 24 h after ICU admission

 HR (BPM), mean ± SD

80.3 ± 16.4

83.5 ± 17.3

0.15

82.3 ± 15.9

81.9 ± 16.3

0.87

 MAP (mmHg), mean ± SD

85.4 ± 15.1

81.7 ± 13.8

0.08

86.2 ± 15.4

82. 7 ± 14.4

0.21

 Lactate (mmol/l), median (IQ 25–75)

2.4 (1.8 - 3.2)

1.8 (0.7 - 2.7)

0.07

2.3 (1.6-2.9)

2.3 (1.1-2.7)

0.41

 CVP (mmHg), median (IQ 25–75)

11 (8.0 – 15)

8 (6.0 - 10.2)

0.00

12 (8.5-15)

8 (6.25-11)

0.002

Fluid administered in first 24 h

 Crystalloids (mL), median (IQ 25–75)

3630 (2685 - 4822)

3500 (2412- 4450)

0.13

4343 (3154- 5620)

3515 (2400 - 4270)

0.00

 Colloids (mL), median (IQ 25–75%)

500 (500 - 1000)

500 (500 - 500)

0.09

500 (500 - 1000)

500 (500 - 500)

0.23

 Number of patients transfused, n (%)

41 (27.9%)

17 (15.6%)

0.02

27 (32.1%)

11 (13.1%)

0.003

 RBCP units/patient, median (IQ 25–75)

1.7 (0.8 – 2.0)

1.0 (0.8 – 2.6)

0.71

0.8 (0.8 – 2.4)

1.0 (0.8 - 3.5)

0.44

ICU LOS (d), median (IQ 25–75)

2 (1-4)

2 (1-4)

0.59

3 (1 – 4)

2 (1 – 4)

0.29

Postoperative LOS (d), median (IQ 25–75)

9 (6-15)

8 (6.25-14)

0.83

11 (7 – 18)

8 (6 – 14)

0.01

Hospital LOS (d), median (IQ 25–75)

17 (11-26)

16 (9-25)

0.30

22 (13 - 30.75)

15 (9 - 23.75)

0.01

Hospital mortality rate

26 (17.7%)

16 (14.8%)

0.54

16 (19.0%)

11 (13.3%)

0.31

  1. Legends: HR heart rate, MAP mean arterial pressure, CVP central venous pressure, SpO 2 peripheral oxygen saturation, RBCP red blood cell pack, ICU intensive care unit, LOS Length of Stay