Original Cohort | Matched Cohort | |||||
---|---|---|---|---|---|---|
Control (n = 147) | Intervention (n = 109) | P | Control (n = 84) | Intervention (n = 84) | P | |
At the time of ICU admission | ||||||
HR (BPM), mean ± SD | 77 ± 16 | 79 ± 14 | 0.51 | 79 ± 16 | 77 ± 14 | 0.40 |
MAP (mmHg), mean ± SD | 93 ± 20 | 89 ± 20 | 0.25 | 89 ± 22 | 90 ± 20 | 0.77 |
Lactate (mmol/l), median (IQ 25–75) | 2.1 (1.5 - 3.5) | 2.6 (1.8 - 3.7) | 0.48 | 2.6 (1.8-4.3) | 2.5 (1.5-3.2) | 0.55 |
CVP (mmHg) median (IQ 25–75) | 10 (6.2 - 13.0) | 9 (5 – 10) | 0.04 | 10 (6.0 – 13) | 9 (5-10) | 0.13 |
At 24 h after ICU admission | ||||||
HR (BPM), mean ± SD | 80.3 ± 16.4 | 83.5 ± 17.3 | 0.15 | 82.3 ± 15.9 | 81.9 ± 16.3 | 0.87 |
MAP (mmHg), mean ± SD | 85.4 ± 15.1 | 81.7 ± 13.8 | 0.08 | 86.2 ± 15.4 | 82. 7 ± 14.4 | 0.21 |
Lactate (mmol/l), median (IQ 25–75) | 2.4 (1.8 - 3.2) | 1.8 (0.7 - 2.7) | 0.07 | 2.3 (1.6-2.9) | 2.3 (1.1-2.7) | 0.41 |
CVP (mmHg), median (IQ 25–75) | 11 (8.0 – 15) | 8 (6.0 - 10.2) | 0.00 | 12 (8.5-15) | 8 (6.25-11) | 0.002 |
Fluid administered in first 24 h | ||||||
Crystalloids (mL), median (IQ 25–75) | 3630 (2685 - 4822) | 3500 (2412- 4450) | 0.13 | 4343 (3154- 5620) | 3515 (2400 - 4270) | 0.00 |
Colloids (mL), median (IQ 25–75%) | 500 (500 - 1000) | 500 (500 - 500) | 0.09 | 500 (500 - 1000) | 500 (500 - 500) | 0.23 |
Number of patients transfused, n (%) | 41 (27.9%) | 17 (15.6%) | 0.02 | 27 (32.1%) | 11 (13.1%) | 0.003 |
RBCP units/patient, median (IQ 25–75) | 1.7 (0.8 – 2.0) | 1.0 (0.8 – 2.6) | 0.71 | 0.8 (0.8 – 2.4) | 1.0 (0.8 - 3.5) | 0.44 |
ICU LOS (d), median (IQ 25–75) | 2 (1-4) | 2 (1-4) | 0.59 | 3 (1 – 4) | 2 (1 – 4) | 0.29 |
Postoperative LOS (d), median (IQ 25–75) | 9 (6-15) | 8 (6.25-14) | 0.83 | 11 (7 – 18) | 8 (6 – 14) | 0.01 |
Hospital LOS (d), median (IQ 25–75) | 17 (11-26) | 16 (9-25) | 0.30 | 22 (13 - 30.75) | 15 (9 - 23.75) | 0.01 |
Hospital mortality rate | 26 (17.7%) | 16 (14.8%) | 0.54 | 16 (19.0%) | 11 (13.3%) | 0.31 |