Fig. 2

Percent changes in diameter in small (≤70 μm) cerebral pial arterioles in the Control a, the Pre b, the Continuous c, and the Post d groups. Before global brain ischemia, Y-27632 produced pial arteriolar dilation (b and c). In the Control group, pial arterioles were constricted during the ischemia, and were dilated temporarily and then were constricted during the reperfusion period. In the Pre group, pial arterioles were not constricted during ischemia, and were temporarily dilated during the reperfusion period. In the Continuous group, pial arterioles were not constricted during the ischemia, and were dilated during the reperfusion period. In the Post group, pial arterioles were constricted but not statistically significant during the ischemia, and were dilated during the reperfusion period. Ba = baseline, Y = after the application of Y-27632, I = initiation of global brain ischemia. * P < 0.05, versus baseline, † P < 0.05, versus the Control group