Table 2 Hemodynamic changes, postoperative pain, awakening agitation, and perioperative adverse events. Values are expressed as mean(standard deviation), number (%), or median (ranges)
Fentanyl (n = 32) | Oxycodone (n = 32) | P value | RRa or MDb (CIc) | |
|---|---|---|---|---|
ΔMBP (mmHg)d | 12.63 (16.76) | 5.51 (18.29) | 0.110 | 7.12 (−1.64−15.89) |
ΔMBP >40 % | 2 (6) | 2 (6) | 1.000 | 1.00 (0.13–7.57) |
ΔHRe | 18.47 (13.74) | 18.71 (16.84) | 0.950 | −0.24 (−7.92−7.44) |
ΔHR >20 % | 15 (47) | 17 (53) | 0.617 | 1.28 (0.48–3.43) |
Pain | 5.00 (3.00–6.75) | 3.00 (2.00–4.00) | <0.001 | 3.00 (0.59–3.41) |
Rescue analgesic | 17 (53) | 9 (28) | 0.042 | 1.89 (0.99−3.59) |
Awakening time (s) | 335.00 (284.50–427.50) | 420.00 (311.00–500.00) | 0.012 | −85.00 (−157.99−12.01) |
Agitation (1,2/3,4) | 11/21 | 24/8 | 0.001 | 0.18 (0.06–0.52) |
Perioperative adverse events | ||||
Cough (before induction) | 5 (16) | 7 (22) | 0.522 | 1.51 (0.43–5.38) |
Dizziness (before induction) | 5 (16) | 0 (0) | 0.020 | NAf |
Oxygen saturation < 92 % (before induction) | 0 (0) | 4 (13) | 0.039 | NA |
Hypotension | 4 (13) | 3 (9) | 0.689 | 0.72 (0.15–3.53) |
Bradycardia | 0 (0) | 3 (9) | 0.076 | NA |