Table 1 Macrohemodynamics
From: Influence of clonidine induced sympathicolysis on anaemia tolerance in anaesthetized pigs
Group | BL1 | BL2 | 25 % | 50 % | 75 % | Hbcrit | |
|---|---|---|---|---|---|---|---|
HR | Saline | 88 (87–107) | 84 (83–107)** | 91 (84–109)** | 107 (85–113) | 128 (95–132) | 130 (98–142)** |
bpm | Clonidine | 88 (79–114) | 57 (53–62)** | 64 (63–76)** | 83 (79–88) | 96 (91–116) | 95 (94–101)** |
MAP | Saline | 88 (69–107) | 87 (70–105)** | 87 (69–99) | 87 (70–96) | 80 (64–93) | 53 (48–59) |
mmHg | Clonidine | 85 (75–90) | 113 (104–124)** | 91 (83–99) | 85 (79–88) | 67 (66–79) | 46 (27–52) |
CI | Saline | 5,9 (5,4-6,3) | 6,0 (5,6-6,3)** | 6,1 (5,4-6,9)** | 6,9 (6,5-8,1)** | 7,3 (7,0-8,5) | 7,9 (7,4-8,5) |
L min−1m−2 | Clonidine | 5,3 (4,6-5,6) | 2,4 (2,2-3,4)** | 4,0 (3,5-4,6)** | 5,1 (4,3-5,7)** | 6,5 (5,7-7,7) | 6,9 (6,0-8,5) |
SVRI | Saline | 2216 (1755–2404) | 2150 (1656–2391)** | 1791 (1509–2072)** | 1500 (1321–1739) | 1526 (989–1547) | 677 (624–830) |
dyn sec cm−5m−2 | Clonidine | 2646 (1997–3196) | 4812 (4649–5471)** | 2678 (2077–3203)** | 1980 (1736–2102) | 1247 (1171–1492) | 428 (354–559) |
PVRI | Saline | 281 (276–332) | 317 (284–361) | 224 (205–308) | 209 (194–221) | 205 (190–264) | 162 (135–173) |
dyn sec cm−5m−2 | Clonidine | 316 (262–389) | 379 (327–457) | 271 (248–360) | 278 (262–285) | 231 (225–248) | 139 (123–177) |
CPP | Saline | 62 (43–71) | 60 (46–70)** | 51 (41–63) | 41 (37–61) | 32 (32–58) | 23 (13–27) |
mmHg | Clonidine | 49 (43–62) | 77 (71–84)** | 53 (47–61) | 46 (37–53) | 35 (25–40) | 6 (2–16) |
LVPsys | Saline | 121 (85–127) | 122 (86–126)** | 109 (87–121)** | 102 (85–115) | 95 (82–113) | 77 (74–80) |
mmHg | Clonidine | 105 (101–113) | 143 (138–157)** | 121 (117–130)** | 114 (106–119) | 100 (90–108) | 70 (52–89) |
LVPedp | Saline | 12 (12–15) | 13 (12–15)** | 15 (13–19)** | 16 (16–19)** | 16 (15–17) | 17 (16–23) |
mmHg | Clonidine | 11 (9–19) | 16 (15–29)** | 17 (16–26)** | 19 (18–26)** | 14 (12–22) | 22 (18–26) |
MPAP | Saline | 22 (21–27) | 23 (22–32) | 24 (22–31) | 25 (22–31) | 26 (22–32) | 26 (24–34) |
mmHg | Clonidine | 25 (23–27) | 26 (24–27) | 25 (24–29) | 27 (25–32) | 30 (25–31) | 27 (25–29) |
LVPdtpmax | Saline | 2210 (1705–2555) | 2160 (1750–2528) | 2400 (1950–3220) | 2830 (2510–3630) | 3630 (2748–3925) | 2080 (1810–2805) |
mmHg s−1 | Clonidine | 2510 (2105–2935) | 1644 (1525–2550) | 2350 (2070–2755) | 2450 (2179–3260) | 2430 (2275–3105) | 1710 (885–2145) |
LVPdtpmin | Saline | −3070 (−5130--2666) | −3120 (−5015--2445) | −3290 (−4420--2465) | −3200 (−4680--2554) | −2850 (−4950--2680) | −1820 (−2840--1195)** |
mmHg−1 | Clonidine | −2510 (−3530--2300) | −3800 (−3890--3235) | −3340 (−4065--2735) | −3080 (−3650--2900) | −2900 (−2950--2170) | −1100 (−1660--785)** |
LVSWI | Saline | 642 (595–820) | 688 (604–825) | 686 (595–790) | 752 (671–896) | 686 (642–749) | 631 (393–668) |
Nm 10−3m−2 | Clonidine | 435 (347–657) | 610 (516–962) | 717 (590–897) | 664 (602–819) | 609 (504–751) | 409 (258–616) |
RVSWI | Saline | 155 (148–216) | 210 (172–231) | 203 (178–238) | 253 (190–286) | 241 (178–272) | 284 (231–299) |
Nm 10−3m−2 | Clonidine | 125 (116–200) | 148 (119–229) | 233 (169–264) | 209 (179–282) | 203 (186–292) | 271 (229–346) |