GROUP A | GROUP B | |
---|---|---|
N. of patients | 210 | 138 |
Gender male. n. (%) | 153 (73) | 95 (69) |
Age (year) | 63.0 ± 11.2 | 70.6 ± 9.9* |
BMI (Kg/m2) | 27.2 ± 6.3 | 26.0 ± 5.6 |
Basal Serum creatinine (mg/L) | 1.0 ± 0.4 | 2.3 ± 1.4* |
Basal Creatinine Clearance (ml/min/1.73 m2) | 106.4 ± 40.7 | 37 ± 16.2* |
Loading dose (mg/kg) | 16.7 ± 4.8 | 18 ± 2 |
Mean time to first VSC (hours) | 40 ± 3 | 41 ± 2 |
Total continuous infusion dosea (g) | 5.4 ± 0.3 | 3.6 ± 0.8* |
Duration of vancomycin therapy (days) | 9.0 ± 1.1 | 9.1 ± 1.6 |
Nephrotoxicity n. (%) | 5 (2.4) | 13 (9.4) |
Concomitant use of nephrotoxic agents: | ||
Vasopressor n. (%) | 32 (15.2) | 25 (18.1) |
Aminoglycoside. n. (%) | 12 (5.7) | 9 (6.5) |
Ace inhibitor n. (%) | 41 (19.5) | 21 (15.2) |
Type of patient at ICU admission: | ||
Medical n. (%) | 119 (56.7) | 69 (50.0) |
Urgent surgery n. ( %) | 7 (3.3) | 23 (16.6)* |
Scheduled surgery n.(%) | 84 (40.0) | 46 (33.4) |
Admission diagnosis. n. (%) | ||
Sepsis | 63 (30 %) | 36 (26) |
Respiratory failure without sepsis | 43 (20.4) | 26 (18.8) |
Post surgery | 80 (38) | 66 (47.8) |
Other | 24 (11.4) | 10 (7.2) |
SAPS II (first 24 h) | 40.3 ± 8.0 | 46.2 ± 7.7* |
ICU deaths. n. (%) | 45 (21.4) | 33 (23.9) |
Site of infection. n.( %) | ||
Low Respiratory Tract | 102 (48.6) | 50 (36.2)* |
Intra-abdominal | 43 (20.5) | 44 (31.8)* |
Bloodstream | 30 (14.3) | 6 (4.3)* |
Skin and soft tissue | 23 (10.9) | 38 (27.5)* |
Other | 12 (5.7) | 0* |
Microorganisms identified. n. (%) | ||
Staphylococci spp | 133 (63.3) | 86 (62.3) |
Enterococci spp | 74 (35.2) | 52 (37.7) |
Streptococci spp | 3 ( 1.4) | 0 |
Vancomycin AUC/ MIC at first determination | 468 ± 79 | 490 ± 84 |