From: The effects of topical and intravenous JM-1232(-) on cerebral pial microvessels of rabbits
Pre | Soff10 | control | JM10 | JM40 | JM60 | JMoff10 | JMoff30 | |
---|---|---|---|---|---|---|---|---|
MAP (mmHg) | 82 ± 15 | 92 ± 13 | 94 ± 91 | 87 ± 12 | 83 ± 12* | 78 ± 12* | 82 ± 11* | 90 ± 10 |
HR (bpm) | 279 ± 15 | 273 ± 15 | 277 ± 21 | 260 ± 13 | 249 ± 27 | 239 ± 22* | 272 ± 17 | 277 ± 16 |
RT(°C) | 39.6 ± 0.8 | 39.6 ± 0.8 | 39.6 ± 0.7 | 39.6 ± 0.7 | 39.6 ± 0.7 | 39.6 ± 0.7 | 39.5 ± 0.6 | 39.6 ± 0.6 |
pH | 7.44 ± 0.02 | 7.42 ± 0.03 | 7.41 ± 0.03 | 7.40 ± 0.03 | 7.40 ± 0.03 | 7.42 ± 0.03 | 7.39 ± 0.03 | 7.39 ± 0.03 |
PaCO2 (mmHg) | 38 ± 3 | 40 ± 2 | 40 ± 2 | 41 ± 4 | 40 ± 3 | 40 ± 2 | 40 ± 2 | 40 ± 1 |
PaO2 (mmHg) | 441 ± 38 | 455 ± 25 | 458 ± 27 | 456 ± 37 | 455 ± 33 | 451 ± 25 | 453 ± 28 | 454 ± 27 |
Na+ (mEq/L) | 141 ± 1 | 141 ± 1 | 141 ± 1 | 142 ± 1 | 141 ± 1 | 142 ± 1 | 142 ± 2 | 142 ± 1 |
K+ (mEq/L) | 3.8 ± 0.2 | 3.8 ± 0.2 | 3.8 ± 0.3 | 3.7 ± 0.2 | 3.7 ± 0.2 | 3.6 ± 0.1 | 3.7 ± 0.1 | 3.8 ± 0.2 |
BS(mg/dl) | 123 ± 8* | 122 ± 7* | 128 ± 13 | 140 ± 12* | 144 ± 13* | 155 ± 19* | 160 ± 19* | 158 ± 20* |
BE | 2.3 ± 3.1 | 2.1 ± 2.7 | 2.2 ± 2.4 | 1.9 ± 2.6 | 1.9 ± 2.2 | 0.7 ± 2.6* | 0.0 ± 2.8* | 0.3 ± 2.1* |
Lactate (mmol/L) | 2.8 ± 0.7 | 2.9 ± 0.5 | 2.8 ± 0.4 | 3.4 ± 0.6* | 4.2 ± 1.0* | 5.0 ± 1.5* | 5.4 ± 1.5* | 5.2 ± 1.2* |